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- Terfenadine abstract "Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was brought to market by Hoechst Marion Roussel (now Sanofi-Aventis) and marketed under various brand names, including Seldane in the United States, Triludan in the United Kingdom, and Teldane in Australia. According to its manufacturer, terfenadine had been used by over 100 million patients worldwide as of 1990. It was superseded by fexofenadine in the 1990s due to the risk of a particular type of disruption of the electrical rhythms of the heart (specifically cardiac arrhythmia caused by QT interval prolongation).Terfenadine is a prodrug, generally completely metabolized to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform.Due to its near complete metabolism by the liver immediately after leaving the gut, terfenadine normally is not measurable in the plasma. Terfenadine itself, however, is cardiotoxic at higher doses, while its major active metabolite is not. Terfenadine, in addition to its antihistamine effects, also acts as a potassium channel blocker (Kv11.1 encoded by the gene hERG). Since its active metabolite is not a potassium channel blocker, no cardiotoxicity is associated with fexofenadine. Toxicity is possible after years of continued use with no previous problems as a result of an interaction with other medications such as erythromycin, or foods such as grapefruit. The addition of, or dosage change in, these CYP3A4 inhibitors makes it harder for the body to metabolize and remove terfenadine. In larger plasma concentrations, it may lead to toxic effects on the heart's rhythm (e.g. ventricular tachycardia and torsades de pointes).".
- Terfenadine atcPrefix "R06".
- Terfenadine atcSuffix "AX12".
- Terfenadine casNumber "50679-08-8".
- Terfenadine drugbank "DB00342".
- Terfenadine fdaUniiCode "7BA5G9Y06Q".
- Terfenadine iupacName "(RS)-1-(4-tert-butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}-butan-1-ol".
- Terfenadine pubchem "5405".
- Terfenadine thumbnail Terfenadine.svg?width=300.
- Terfenadine wikiPageExternalLink 800A.htm.
- Terfenadine wikiPageID "2161447".
- Terfenadine wikiPageRevisionID "639836730".
- Terfenadine atcPrefix "R06".
- Terfenadine atcSuffix "AX12".
- Terfenadine c "32".
- Terfenadine casNumber "50679".
- Terfenadine chembl "17157".
- Terfenadine chemspiderid "5212".
- Terfenadine drugName "Terfenadine".
- Terfenadine drugbank "DB00342".
- Terfenadine eliminationHalfLife "12600.0".
- Terfenadine h "41".
- Terfenadine hasPhotoCollection Terfenadine.
- Terfenadine imagename "1".
- Terfenadine inchi "1".
- Terfenadine inchikey "GUGOEEXESWIERI-UHFFFAOYAL".
- Terfenadine iupacName "-1".
- Terfenadine iupharLigand "2608".
- Terfenadine kegg "D00521".
- Terfenadine legalStatus "Withdrawn".
- Terfenadine medlineplus "a600034".
- Terfenadine molecularWeight "471.673".
- Terfenadine n "1".
- Terfenadine o "2".
- Terfenadine pregnancyUs "C".
- Terfenadine proteinBound "70.0".
- Terfenadine pubchem "5405".
- Terfenadine smiles "OCC4CCNCC4".
- Terfenadine stdinchi "1".
- Terfenadine stdinchikey "GUGOEEXESWIERI-UHFFFAOYSA-N".
- Terfenadine tradename "Seldane, Triludan, Teldane".
- Terfenadine unii "7".
- Terfenadine verifiedfields "changed".
- Terfenadine verifiedrevid "470602363".
- Terfenadine width "200".
- Terfenadine subject Category:1985_introductions.
- Terfenadine subject Category:1997_disestablishments.
- Terfenadine subject Category:Alcohols.
- Terfenadine subject Category:H1_receptor_antagonists.
- Terfenadine subject Category:Piperidines.
- Terfenadine subject Category:Prodrugs.
- Terfenadine subject Category:Withdrawn_drugs.
- Terfenadine type Adversary109773245.
- Terfenadine type CausalAgent100007347.
- Terfenadine type H1ReceptorAntagonists.
- Terfenadine type LivingThing100004258.
- Terfenadine type Object100002684.
- Terfenadine type Organism100004475.
- Terfenadine type Person100007846.
- Terfenadine type PhysicalEntity100001930.
- Terfenadine type Whole100003553.
- Terfenadine type YagoLegalActor.
- Terfenadine type YagoLegalActorGeo.
- Terfenadine type Drug.
- Terfenadine type DrugProduct.
- Terfenadine type Thing.
- Terfenadine type Q8386.
- Terfenadine comment "Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was brought to market by Hoechst Marion Roussel (now Sanofi-Aventis) and marketed under various brand names, including Seldane in the United States, Triludan in the United Kingdom, and Teldane in Australia. According to its manufacturer, terfenadine had been used by over 100 million patients worldwide as of 1990.".
- Terfenadine label "Terfenadin".
- Terfenadine label "Terfenadina".
- Terfenadine label "Terfenadine".
- Terfenadine sameAs Terfenadin.
- Terfenadine sameAs Terfenadina.
- Terfenadine sameAs m.06rc_9.
- Terfenadine sameAs Q417909.
- Terfenadine sameAs Q417909.
- Terfenadine sameAs DB00342.
- Terfenadine sameAs Terfenadine.
- Terfenadine wasDerivedFrom Terfenadine?oldid=639836730.
- Terfenadine depiction Terfenadine.svg.
- Terfenadine isPrimaryTopicOf Terfenadine.
- Terfenadine name "Terfenadine".