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- LY-404,039 abstract "LY-404,039 is an amino acid analog drug that acts as a highly selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. Pharmacological research has focused on its potential antipsychotic and anxiolytic effects. LY-404,039 is intended as a treatment for schizophrenia and other psychotic and anxiety disorders by modulating glutamatergic activity and reducing presynaptic release of glutamate at synapses in limbic and forebrain areas relevant to these disorders. Human studies investigating therapeutic use of LY-404,039 have focused on the prodrug LY-214,0023, a methionine amide of LY-404,039 (also called pomaglumetad methionil or LY-214,0023 monohydrate) since LY-404,039 exhibits low oral absorption and bioavailability in humans.Early human trials using this prodrug form of LY-404,039 gave encouraging results. However, pharmaceutical company Eli Lilly terminated further development of the compound in 2012 after it failed in phase II clinical trials. In September 2013, the results of a randomized, placebo-controlled clinical trial investigating the impact of adjunctive LY-214,0023 on prominent negative symptoms in schizophrenia was published and failed to demonstrate any benefit.".
- LY-404,039 atcPrefix "N".
- LY-404,039 iupacName "(-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid".
- LY-404,039 pubchem "9834591".
- LY-404,039 thumbnail LY404039_structure.png?width=300.
- LY-404,039 wikiPageID "23624907".
- LY-404,039 wikiPageRevisionID "643444710".
- LY-404,039 atcPrefix "N".
- LY-404,039 c "7".
- LY-404,039 chemspiderid "8010312".
- LY-404,039 h "9".
- LY-404,039 hasPhotoCollection LY-404,039.
- LY-404,039 inchi "1".
- LY-404,039 inchikey "AVDUGNCTZRCAHH-MDASVERJBY".
- LY-404,039 iupacName "--4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid".
- LY-404,039 legalStatus "Not FDA-Approved".
- LY-404,039 molecularWeight "235.214".
- LY-404,039 n "1".
- LY-404,039 o "6".
- LY-404,039 pubchem "9834591".
- LY-404,039 s "1".
- LY-404,039 smiles "C1[C@]N".
- LY-404,039 stdinchi "1".
- LY-404,039 stdinchikey "AVDUGNCTZRCAHH-MDASVERJSA-N".
- LY-404,039 verifiedfields "changed".
- LY-404,039 verifiedrevid "447658602".
- LY-404,039 watchedfields "changed".
- LY-404,039 width "200".
- LY-404,039 subject Category:MGlu2_receptor_agonists.
- LY-404,039 subject Category:MGlu3_receptor_agonists.
- LY-404,039 subject Category:Schizophrenia.
- LY-404,039 type Drug.
- LY-404,039 type DrugProduct.
- LY-404,039 type Thing.
- LY-404,039 type Q8386.
- LY-404,039 comment "LY-404,039 is an amino acid analog drug that acts as a highly selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. Pharmacological research has focused on its potential antipsychotic and anxiolytic effects.".
- LY-404,039 label "LY-404,039".
- LY-404,039 sameAs m.06zkyqc.
- LY-404,039 sameAs Q6460431.
- LY-404,039 sameAs Q6460431.
- LY-404,039 wasDerivedFrom LY-404,039?oldid=643444710.
- LY-404,039 depiction LY404039_structure.png.
- LY-404,039 isPrimaryTopicOf LY-404,039.