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Matches in DBpedia 2015-04 for { <http://dbpedia.org/resource/Insulin_detemir> ?p ?o }

• Insulin_detemir abstract "Insulin detemir is a long-acting human insulin analogue for maintaining the basal level of insulin. Novo Nordisk markets it under the trade name Levemir. It is an insulin analogue in which a fatty acid (myristic acid) is bound to the lysine amino acid at position B29. It is quickly absorbed after which it binds to albumin in the blood through its fatty acid at position B29. It then slowly dissociates from this complex.In a clinical study that compared the efficacy and safety of using Levemir for the treatment of patients with type 2 diabetes who had suboptimal glycemic control while receiving maximally tolerated doses of metformin and sulfonylurea (common tablet therapies for type 2 diabetes), it was found that, "At 24 weeks, HbA1c (glycosylated hemoglobin) had decreased by 1.8 and 1.9% (from 8.6 to 6.8 and from 8.5 to 6.6%) for detemir and NPH, respectively (NS). In both groups, 70% of participants achieved an HbA1c of 7.0%, but the proportion achieving this without hypoglycemia was higher with insulin detemir than with NPH insulin (26 vs. 16%, P = 0.008). Compared with NPH insulin, the risk for all hypoglycemia with insulin detemir was reduced by 47% (P < 0.001) and nocturnal hypoglycemia by 55% (P < 0.001). Mean weight gain was 1.2 kg with insulin detemir and 2.8 kg with NPH insulin (P < 0.001), and the difference in baseline-adjusted final weight was –1.58 (P < 0.001)."In short, it was found that insulin detemir reduced HbA1c to target levels of 7.0% for 70% of patients, similar to human basal insulin, NPH, but without the same risk of hypoglycemia and with somewhat less weight gain.Regarding weight gain compared to NPH insulin, the The Levemir package insert states the following disclaimer:"LEVEMIR was associated with somewhat less weight gain than NPH (Table 4). Whether these observed differences represent true differences in the effects of LEVEMIR and NPH insulin is not known, since these trials were not blinded and the protocols (e.g., diet and exercise instructions and monitoring) were not specifically directed at exploring hypotheses related to weight effects of the treatments compared. The clinical significance of the observed differences has not been established..."Levemir Package Insert; Adverse Reactions > Weight GainIn addition, the safety and efficacy of insulin detemir (Levemir®) in real life clinical practice was evaluated in the A1chieve study.On June 13, 2009, the U.S. Food and Drug Administration (FDA) issued a public health advisory for Levemir insulin after learning that 129,000 stolen vials reappeared and were being sold in the U.S. market. The FDA warned that the stolen vials "may not have been stored and handled properly and may be dangerous for patients to use." The stolen vials were identified as lots XZF0036, XZF0037, and XZF0038.".
• Insulin_detemir atcPrefix "A10".
• Insulin_detemir atcSuffix "AE05".
• Insulin_detemir bioavailability "60.0".
• Insulin_detemir casNumber "169148-63-4".
• Insulin_detemir drugbank "DB01307".
• Insulin_detemir fdaUniiCode "4FT78T86XV".
• Insulin_detemir wikiPageExternalLink NEJMoa075392,.
• Insulin_detemir wikiPageExternalLink www.a1chieve.com.
• Insulin_detemir wikiPageExternalLink ucm166358.htm.
• Insulin_detemir wikiPageExternalLink www.levemir-us.com.
• Insulin_detemir wikiPageExternalLink prescribing_information.pdf.
• Insulin_detemir wikiPageExternalLink ?p=af5e2f613a0f4c6690f8fdc920f48bd6&pi=5,.
• Insulin_detemir wikiPageID "11154449".
• Insulin_detemir wikiPageRevisionID "596314897".
• Insulin_detemir atcPrefix "A10".
• Insulin_detemir atcSuffix "AE05".
• Insulin_detemir bioavailability "60.0".
• Insulin_detemir c "267".
• Insulin_detemir casNumber "169148".
• Insulin_detemir chemspiderid "NA".
• Insulin_detemir drugName "Insulin Detemir".
• Insulin_detemir drugbank "DB01307".
• Insulin_detemir eliminationHalfLife "25200.0".
• Insulin_detemir h "402".
• Insulin_detemir hasPhotoCollection Insulin_detemir.
• Insulin_detemir kegg "D04539".
• Insulin_detemir legalUs "Rx-only".
• Insulin_detemir medlineplus "a606012".
• Insulin_detemir molecularWeight "5913".
• Insulin_detemir n "64".
• Insulin_detemir o "76".
• Insulin_detemir pregnancyUs "B".
• Insulin_detemir routesOfAdministration "Subcutaneous".
• Insulin_detemir s "6".
• Insulin_detemir tradename "Levemir".
• Insulin_detemir unii "4".
• Insulin_detemir verifiedfields "changed".
• Insulin_detemir verifiedrevid "464363066".
• Insulin_detemir subject Category:Insulin_therapies.
• Insulin_detemir type Abstraction100002137.
• Insulin_detemir type Act100030358.
• Insulin_detemir type Activity100407535.
• Insulin_detemir type Care100654885.
• Insulin_detemir type Event100029378.
• Insulin_detemir type InsulinTherapies.
• Insulin_detemir type MedicalCare100657604.
• Insulin_detemir type PsychologicalFeature100023100.
• Insulin_detemir type Therapy100661091.
• Insulin_detemir type Treatment100658082.
• Insulin_detemir type Work100575741.
• Insulin_detemir type YagoPermanentlyLocatedEntity.
• Insulin_detemir type Drug.
• Insulin_detemir type DrugProduct.
• Insulin_detemir type Thing.
• Insulin_detemir type Q8386.
• Insulin_detemir comment "Insulin detemir is a long-acting human insulin analogue for maintaining the basal level of insulin. Novo Nordisk markets it under the trade name Levemir. It is an insulin analogue in which a fatty acid (myristic acid) is bound to the lysine amino acid at position B29. It is quickly absorbed after which it binds to albumin in the blood through its fatty acid at position B29.".
• Insulin_detemir label "Insulin detemir".
• Insulin_detemir label "Insulin detemir".
• Insulin_detemir label "Insulina detemir".
• Insulin_detemir label "Insuline detemir".
• Insulin_detemir sameAs Insulin_detemir.
• Insulin_detemir sameAs Insuline_detemir.
• Insulin_detemir sameAs Insulina_detemir.
• Insulin_detemir sameAs m.02r1wl7.
• Insulin_detemir sameAs Q410965.
• Insulin_detemir sameAs Q410965.
• Insulin_detemir sameAs INSULIN_DETEMIR.
• Insulin_detemir sameAs DB01307.
• Insulin_detemir sameAs Insulin_detemir.
• Insulin_detemir wasDerivedFrom Insulin_detemir?oldid=596314897.
• Insulin_detemir isPrimaryTopicOf Insulin_detemir.
• Insulin_detemir name "Insulin Detemir".