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- Icotinib abstract "Icotinib Hydrochloride (BPI-2009H), or Icotinib, is a highly selective, first generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). EGFR is an oncogenic driver and patients with somatic mutations, particularly an exon 19 deletion or exon 21 L858R mutation, within the tyrosine kinase domain have activating mutations that lead to unchecked cell proliferation. Overexpression of EGFR causes inappropriate activation of the anti-apoptotic Ras signaling pathway, found in many different types of cancer. Icotinib is a quinazoline derivative that binds reversibly to the ATP binding site of the EGFR protein, preventing completion of the signal transduction cascade.".
- Icotinib bioavailability "52.0".
- Icotinib casNumber "1204313-51-8".
- Icotinib drugbank "DB00530".
- Icotinib fdaUniiCode "9G6U5L461Q".
- Icotinib pubchem "22024915".
- Icotinib thumbnail Icotinib.svg?width=300.
- Icotinib wikiPageID "41340389".
- Icotinib wikiPageRevisionID "632429199".
- Icotinib bioavailability "52.0".
- Icotinib c "22".
- Icotinib casNumber "1204313".
- Icotinib chemspiderid "10762174".
- Icotinib drugbank "DB00530".
- Icotinib eliminationHalfLife "19800.0".
- Icotinib excretion ">98% as metabolites, of which >90% via faeces, 9% via urine".
- Icotinib h "21".
- Icotinib inchi "1".
- Icotinib inchikey "QQLKULDARVNMAL-UHFFFAOYSA-N".
- Icotinib metabolism "Hepatic".
- Icotinib molecularWeight "391.42".
- Icotinib n "3".
- Icotinib o "4".
- Icotinib pubchem "22024915".
- Icotinib routesOfAdministration "Oral tablets".
- Icotinib smiles "C#CC1=CCNC2=NC=NC3=CC4=COCCOCCOCCO4".
- Icotinib stdinchi "1".
- Icotinib stdinchikey "QQLKULDARVNMAL-UHFFFAOYSA-N".
- Icotinib tradename "Conmana, Icotinib".
- Icotinib unii "9".
- Icotinib verifiedrevid "464189825".
- Icotinib subject Category:Quinazolines.
- Icotinib subject Category:Tyrosine_kinase_inhibitors.
- Icotinib type Drug.
- Icotinib type Thing.
- Icotinib type Q8386.
- Icotinib comment "Icotinib Hydrochloride (BPI-2009H), or Icotinib, is a highly selective, first generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). EGFR is an oncogenic driver and patients with somatic mutations, particularly an exon 19 deletion or exon 21 L858R mutation, within the tyrosine kinase domain have activating mutations that lead to unchecked cell proliferation.".
- Icotinib label "Icotinib".
- Icotinib sameAs m.0zn0bxh.
- Icotinib sameAs Q16868421.
- Icotinib sameAs Q16868421.
- Icotinib wasDerivedFrom Icotinib?oldid=632429199.
- Icotinib depiction Icotinib.svg.
- Icotinib isPrimaryTopicOf Icotinib.
