DBpedia 2015-04

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Galantamine abstract "Galantamine (Nivalin, Razadyne, Razadyne ER, Reminyl, Lycoremine) is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments, in particular those of vascular origin. It is an alkaloid that is obtained synthetically or from the bulbs and flowers of Galanthus caucasicus (Caucasian snowdrop, Voronov's snowdrop), Galanthus woronowii (Amaryllidaceae) and related genera like Narcissus (daffodil), Leucojum (snowflake), and Lycoris including Lycoris radiata (Red Spider Lily).Studies of usage in modern medicine began in the Soviet Union in the 1950s. The active ingredient was extracted, identified, and studied, in particular in relation to its acetylcholinesterase (AChE)-inhibiting properties. The bulk of the work was carried out by Soviet pharmacologists M. D. Mashkovsky and R. P. Kruglikova–Lvova, beginning in 1951. The work of Mashkovsky and Kruglikova-Lvova was the first published work that demonstrated the AChE-inhibiting properties of galantamine.The first industrial process was developed in Bulgaria by prof. Paskov in 1959 (Nivalin, Sopharma) from a species traditionally used as a popular medicine in Eastern Europe, and, thus, the idea for developing a medicine from these species seems to be based on the local use (i.e., an ethnobotany-driven drug discovery).Galantamine has been used for decades in Eastern Europe and Russia for various indications such as treatment of myasthenia, myopathy, and sensory and motor dysfunction associated with disorders of the central nervous system. In the US, it is FDA approved for the treatment of Alzheimer's disease.It is available in both a prescription form and as an over the counter supplement.".
Galantamine atcPrefix "N06".
Galantamine atcSuffix "DA04".
Galantamine bioavailability "80.0".
Galantamine casNumber "357-70-0".
Galantamine chEBI "42944".
Galantamine drugbank "DB00674".
Galantamine fdaUniiCode "0D3Q044KCA".
Galantamine iupacName "(4aS,6R,8aS)- 5,6,9,10,11,12- hexahydro- 3-methoxy- 11-methyl- 4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin- 6-ol".
Galantamine pubchem "9651".
Galantamine thumbnail Galantamine.svg?width=300.
Galantamine wikiPageExternalLink ocashort?id=1DX6.
Galantamine wikiPageExternalLink AChE_inhibitors_and_substrates_%28Part_II%29.
Galantamine wikiPageExternalLink quips?story=AChE.
Galantamine wikiPageExternalLink www.pdbe.org.
Galantamine wikiPageExternalLink 1dx6.
Galantamine wikiPageExternalLink www.razadyneer.com.
Galantamine wikiPageID "1214927".
Galantamine wikiPageRevisionID "642235853".
Galantamine atcPrefix "N06".
Galantamine atcSuffix "DA04".
Galantamine bioavailability "80".
Galantamine c "17".
Galantamine casNumber "357".
Galantamine chebi "42944".
Galantamine chembl "659".
Galantamine chemspiderid "9272".
Galantamine drugbank "DB00674".
Galantamine eliminationHalfLife "25200.0".
Galantamine excretion "Renal , fecal".
Galantamine h "21".
Galantamine hasPhotoCollection Galantamine.
Galantamine image "Galantamine ball-and-stick.png".
Galantamine inchi "1".
Galantamine inchikey "ASUTZQLVASHGKV-JDFRZJQEBY".
Galantamine iupacName "-569101112".
Galantamine kegg "D04292".
Galantamine legalStatus "Rx".
Galantamine medlineplus "a699058".
Galantamine meltingPoint "126.5".
Galantamine metabolism "Hepatic partially CYP450:CYP2D6/3A4 substrate".
Galantamine molecularWeight "287.354".
Galantamine n "1".
Galantamine o "3".
Galantamine pdbLigand "GNT".
Galantamine pregnancyCategory "B".
Galantamine proteinBound "18.0".
Galantamine pubchem "9651".
Galantamine routesOfAdministration "Oral".
Galantamine smiles "OC".
Galantamine stdinchi "1".
Galantamine stdinchikey "ASUTZQLVASHGKV-JDFRZJQESA-N".
Galantamine tradename "Razadyne".
Galantamine unii "0".
Galantamine verifiedrevid "461118063".
Galantamine width "175".
Galantamine subject Category:Acetylcholinesterase_inhibitors.
Galantamine subject Category:Alcohols.
Galantamine subject Category:Antidementia_agents.
Galantamine subject Category:Benzazepines.
Galantamine subject Category:Janssen_Pharmaceutica.
Galantamine subject Category:Nootropics.
Galantamine subject Category:Phenol_ethers.
Galantamine type Abstraction100002137.
Galantamine type Agent114778436.
Galantamine type Alcohol107884567.
Galantamine type Alcohols.
Galantamine type Beverage107881800.
Galantamine type CausalAgent100007347.
Galantamine type Drug103247620.
Galantamine type DrugOfAbuse103248958.
Galantamine type Element114840755.
Galantamine type Fluid114939900.
Galantamine type Food100021265.
Galantamine type Liquid114940386.
Galantamine type Matter100020827.
Galantamine type Part113809207.
Galantamine type PhenolEthers.
Galantamine type PhysicalEntity100001930.
Galantamine type Quintessence114847103.
Galantamine type Relation100031921.
Galantamine type Substance100019613.
Galantamine type Substance100020090.
Galantamine type Drug.
Galantamine type DrugProduct.
Galantamine type Thing.
Galantamine type Q8386.
Galantamine comment "Galantamine (Nivalin, Razadyne, Razadyne ER, Reminyl, Lycoremine) is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments, in particular those of vascular origin.".
Galantamine label "Galantamin".
Galantamine label "Galantamina".
Galantamine label "Galantamina".
Galantamine label "Galantamina".
Galantamine label "Galantamina".
Galantamine label "Galantamine".
Galantamine label "Galantamine".
Galantamine label "Galantamine".
Galantamine label "Галантамин".
Galantamine label "ガランタミン".
Galantamine sameAs Galantamin.
Galantamine sameAs Galantamina.