Matches in DBpedia 2015-04 for { <http://dbpedia.org/resource/Chlorpromazine> ?p ?o }
- Chlorpromazine abstract "Chlorpromazine (CPZ) — marketed, as chlorpromazine hydrochloride, in the United States as Thorazine and elsewhere as Largactil and Megaphen — is a dopamine antagonist of the typical anti-psychotic class of medications possessing additional anti-adrenergic, anti-serotonergic, anti-cholinergic and anti-histaminergic properties used to treat schizophrenia. First synthesized on December 11, 1951, chlorpromazine was the first drug developed with specific antipsychotic action and would serve as the prototype for the phenothiazine class of drugs, which comprises several other agents. The introduction of chlorpromazine during the 1950s into clinical use has been described as the single greatest advance in the history of psychiatric care, dramatically improving as it did the prognosis of patients in psychiatric hospitals worldwide.Chlorpromazine works on a variety of receptors in the central nervous system, producing potent anticholinergic, antidopaminergic, antihistaminic, and antiadrenergic effects. Both the clinical indications and side effect profile of CPZ are determined by the broadness of its action: its anticholinergic properties cause constipation, sedation, and hypotension but also help relieve nausea. It also has anxiolytic (anxiety-relieving) properties. Its antidopaminergic properties can cause extrapyramidal symptoms, such as akathisia (restlessness, where the patient walks almost constantly, despite having nowhere to go due to mandatory confinement) and dystonia. It is known to cause tardive dyskinesia, which can be irreversible. In acute settings, it is often administered as a syrup, which has a faster onset of action than tablets, and it can also be given by intramuscular injection. IV administration is very irritating and is not advised; its use is limited to severe hiccups, surgery, and tetanus.Chlorpromazine is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.".
- Chlorpromazine atcPrefix "N05".
- Chlorpromazine atcSuffix "AA01".
- Chlorpromazine bioavailability "10.0".
- Chlorpromazine casNumber "50-53-3".
- Chlorpromazine casSupplemental "(free base)".
- Chlorpromazine casSupplemental "(hydrochloride)".
- Chlorpromazine chEBI "3647".
- Chlorpromazine drugbank "DB00477".
- Chlorpromazine fdaUniiCode "U42B7VYA4P".
- Chlorpromazine iupacName "3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-propan-1-amine".
- Chlorpromazine pubchem "2726".
- Chlorpromazine thumbnail Chlorpromazine2DACS.svg?width=300.
- Chlorpromazine wikiPageExternalLink thorazine-adverts.html.
- Chlorpromazine wikiPageExternalLink dpdirect.jsp?name=Chlorpromazine.
- Chlorpromazine wikiPageExternalLink methods.htm.
- Chlorpromazine wikiPageExternalLink tardive.htm.
- Chlorpromazine wikiPageID "148980".
- Chlorpromazine wikiPageRevisionID "638515980".
- Chlorpromazine atcPrefix "N05".
- Chlorpromazine atcSuffix "AA01".
- Chlorpromazine bioavailability "10".
- Chlorpromazine c "17".
- Chlorpromazine casNumber "50".
- Chlorpromazine chebi "3647".
- Chlorpromazine chembl "71".
- Chlorpromazine chemspiderid "2625".
- Chlorpromazine cl "1".
- Chlorpromazine drugbank "DB00477".
- Chlorpromazine eliminationHalfLife "25200.0".
- Chlorpromazine excretion "Urine".
- Chlorpromazine h "19".
- Chlorpromazine hasPhotoCollection Chlorpromazine.
- Chlorpromazine image "Chlorpromazine.gif".
- Chlorpromazine inchi "1".
- Chlorpromazine iupacName "3".
- Chlorpromazine iupharLigand "83".
- Chlorpromazine kegg "D00270".
- Chlorpromazine legalAu "S4".
- Chlorpromazine legalCa "Rx-only".
- Chlorpromazine legalUk "POM".
- Chlorpromazine legalUs "Rx-only".
- Chlorpromazine licenceUs "Chlorpromazine".
- Chlorpromazine medlineplus "a682040".
- Chlorpromazine metabolism "Hepatic, mostly CYP2D6-mediated".
- Chlorpromazine molecularWeight "318.86".
- Chlorpromazine molecularWeight "355.33".
- Chlorpromazine n "2".
- Chlorpromazine pregnancyAu "C".
- Chlorpromazine pregnancyUs "C".
- Chlorpromazine proteinBound "90".
- Chlorpromazine pubchem "2726".
- Chlorpromazine routesOfAdministration "Oral , rectal, IM, IV infusion".
- Chlorpromazine s "1".
- Chlorpromazine smiles "CNCCCN1c2ccccc2Sc3c1ccCl".
- Chlorpromazine stdinchi "1".
- Chlorpromazine stdinchikey "ZPEIMTDSQAKGNT-UHFFFAOYSA-N".
- Chlorpromazine tradename "Largactil, Thorazine".
- Chlorpromazine unii "U42B7VYA4P".
- Chlorpromazine verifiedrevid "443519547".
- Chlorpromazine watchedfields "changed".
- Chlorpromazine width "200".
- Chlorpromazine width "250".
- Chlorpromazine subject Category:Antiemetics.
- Chlorpromazine subject Category:Organochlorides.
- Chlorpromazine subject Category:Phenothiazines.
- Chlorpromazine type Drug.
- Chlorpromazine type DrugProduct.
- Chlorpromazine type Thing.
- Chlorpromazine type Q8386.
- Chlorpromazine comment "Chlorpromazine (CPZ) — marketed, as chlorpromazine hydrochloride, in the United States as Thorazine and elsewhere as Largactil and Megaphen — is a dopamine antagonist of the typical anti-psychotic class of medications possessing additional anti-adrenergic, anti-serotonergic, anti-cholinergic and anti-histaminergic properties used to treat schizophrenia.".
- Chlorpromazine label "Chloorpromazine".
- Chlorpromazine label "Chloropromazyna".
- Chlorpromazine label "Chlorpromazin".
- Chlorpromazine label "Chlorpromazin".
- Chlorpromazine label "Chlorpromazine".
- Chlorpromazine label "Chlorpromazine".
- Chlorpromazine label "Clorpromazina".
- Chlorpromazine label "Clorpromazina".
- Chlorpromazine label "Clorpromazina".
- Chlorpromazine label "Klorpromazin".
- Chlorpromazine label "Klórpromazin".
- Chlorpromazine label "Хлорпромазин".
- Chlorpromazine label "Хлорпромазин".
- Chlorpromazine label "クロルプロマジン".
- Chlorpromazine seeAlso List_of_adverse_effects_for_chlorpromazine.
- Chlorpromazine sameAs Chlorpromazin.
- Chlorpromazine sameAs Chlorpromazin.
- Chlorpromazine sameAs Χλωροπρομαζίνη.
- Chlorpromazine sameAs Clorpromazina.
- Chlorpromazine sameAs Chlorpromazine.
- Chlorpromazine sameAs Clorpromazina.
- Chlorpromazine sameAs クロルプロマジン.
- Chlorpromazine sameAs Chloorpromazine.
- Chlorpromazine sameAs Chloropromazyna.
- Chlorpromazine sameAs Clorpromazina.
- Chlorpromazine sameAs m.0133fz.
- Chlorpromazine sameAs Q407972.
- Chlorpromazine sameAs Q407972.
- Chlorpromazine sameAs chlorpromazine.