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- Abzyme abstract "An abzyme (from antibody and enzyme), also called catmab (from catalytic monoclonal antibody), and most often called catalytic antibody, is a monoclonal antibody with catalytic activity. Abzymes are usually raised in lab animals immunized against synthetic haptans, but some natural abzymes can be found in normal humans (anti-vasoactive intestinal peptide autoantibodies) and in patients with autoimmune diseases such as systemic lupus erythematosus, where they can bind to and hydrolyze DNA. To date abzymes display only weak, modest catalytic activity and have not proved to be of any practical use. They are, however, subjects of considerable academic interest. Studying them has yielded important insights into reaction mechanisms, enzyme structure and function, catalysis, and the immune system itself.Enzymes function by lowering the activation energy of the transition state of a chemical reaction, thereby enabling the formation of an otherwise less-favorable molecular intermediate between the reactant(s) and the product(s). If an antibody is developed to bind to a molecule that's structurally and electronically similar to the transition state of a given chemical reaction, the developed antibody will bind to, and stabilize, the transition state, just like a natural enzyme, lowering the activation energy of the reaction, and thus catalyzing the reaction. By raising an antibody to bind to a stable transition-state analog, a new and unique type of enzyme is produced.So far, all catalytic antibodies produced have displayed only modest, weak catalytic activity. The reasons for low catalytic activity for these molecules have been widely discussed. Possibilities indicate that factors beyond the binding site may play an important, in particular through protein dynamics. Some abzymes have been engineered to use metal ions and other cofactors to improve their catalytic activity.".
- Abzyme wikiPageID "1908".
- Abzyme wikiPageRevisionID "634150633".
- Abzyme hasPhotoCollection Abzyme.
- Abzyme subject Category:Monoclonal_antibodies.
- Abzyme type Abstraction100002137.
- Abzyme type Antibody115027189.
- Abzyme type Chemical114806838.
- Abzyme type Compound114818238.
- Abzyme type Macromolecule114944888.
- Abzyme type Material114580897.
- Abzyme type Matter100020827.
- Abzyme type Molecule114682133.
- Abzyme type MonoclonalAntibodies.
- Abzyme type MonoclonalAntibody115029781.
- Abzyme type OrganicCompound114727670.
- Abzyme type Part113809207.
- Abzyme type PhysicalEntity100001930.
- Abzyme type Protein114728724.
- Abzyme type Relation100031921.
- Abzyme type Substance100019613.
- Abzyme type Thing100002452.
- Abzyme type Unit109465459.
- Abzyme comment "An abzyme (from antibody and enzyme), also called catmab (from catalytic monoclonal antibody), and most often called catalytic antibody, is a monoclonal antibody with catalytic activity. Abzymes are usually raised in lab animals immunized against synthetic haptans, but some natural abzymes can be found in normal humans (anti-vasoactive intestinal peptide autoantibodies) and in patients with autoimmune diseases such as systemic lupus erythematosus, where they can bind to and hydrolyze DNA.".
- Abzyme label "Abzim".
- Abzyme label "Abzima".
- Abzyme label "Abzima".
- Abzyme label "Abzyme".
- Abzyme label "Abzyme".
- Abzyme label "Abzymy".
- Abzyme label "Anticorps catalytique".
- Abzyme label "Абзимы".
- Abzyme label "抗体酵素".
- Abzyme sameAs Abzyme.
- Abzyme sameAs Abzima.
- Abzyme sameAs Anticorps_catalytique.
- Abzyme sameAs Abzima.
- Abzyme sameAs 抗体酵素.
- Abzyme sameAs Abzymy.
- Abzyme sameAs m.0v2s.
- Abzyme sameAs Q336782.
- Abzyme sameAs Q336782.
- Abzyme sameAs Abzyme.
- Abzyme wasDerivedFrom Abzyme?oldid=634150633.
- Abzyme isPrimaryTopicOf Abzyme.