Matches in DBpedia 2016-04 for { <http://www.genome.jp/dbget-bin/www_bget?hsa05034> ?p ?o }
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- www_bget?hsa05034 accessdate "2015-02-09".
- www_bget?hsa05034 date "2014-10-29".
- www_bget?hsa05034 isCitedBy Ethanol.
- www_bget?hsa05034 isCitedBy Neuropharmacology.
- www_bget?hsa05034 quote "As one of the primary mediators of the rewarding effects of alcohol, dopaminergic ventral tegmental area projections to the nucleus accumbens have been identified. Acute exposure to alcohol stimulates dopamine release into the NAc, which activates D1 receptors, stimulating PKA signaling and subsequent CREB-mediated gene expression, whereas chronic alcohol exposure leads to an adaptive downregulation of this pathway, in particular of CREB function. The decreased CREB function in the NAc may promote the intake of drugs of abuse to achieve an increase in reward and thus may be involved in the regulation of positive affective states of addiction. PKA signaling also affects NMDA receptor activity and may play an important role in neuroadaptation in response to chronic alcohol exposure.".
- www_bget?hsa05034 quote "As one of the primary mediators of the rewarding effects of alcohol, dopaminergic ventral tegmental area projections to the nucleus accumbens have been identified. Acute exposure to alcohol stimulates dopamine release into the NAc, which activates D1 receptors, stimulating PKA signaling and subsequent CREB-mediated gene expression, whereas chronic alcohol exposure leads to an adaptive downregulation of this pathway, in particular of CREB function. The decreased CREB function in the NAc may promote the intake of drugs of abuse to achieve an increase in reward and thus may be involved in the regulation of positive affective states of addiction. PKA signaling also affects NMDA receptor activity and may play an important role in neuroadaptation in response to chronic alcohol exposure.".
- www_bget?hsa05034 title "Alcoholism – Homo sapiens Database entry".
- www_bget?hsa05034 url "http://www.genome.jp/dbget-bin/www_bget?hsa05034".
- www_bget?hsa05034 website "KEGG Pathway".