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- Q910897 subject Q7213749.
- Q910897 abstract "The histone code is a hypothesis that the transcription of genetic information encoded in DNA is in part regulated by chemical modifications to histone proteins, primarily on their unstructured ends. Together with similar modifications such as DNA methylation it is part of the epigenetic code. Histones associate with DNA to form nucleosomes, which themselves bundle to form chromatin fibers, which in turn make up the more familiar chromosome. Histones are globular proteins with a flexible N-terminus (taken to be the tail) that protrudes from the nucleosome. Many of the histone tail modifications correlate very well to chromatin structure and both histone modification state and chromatin structure correlate well to gene expression levels. The critical concept of the histone code hypothesis is that the histone modifications serve to recruit other proteins by specific recognition of the modified histone via protein domains specialized for such purposes, rather than through simply stabilizing or destabilizing the interaction between histone and the underlying DNA. These recruited proteins then act to alter chromatin structure actively or to promote transcription.For details of gene expression regulation by histone modifications see table below.".
- Q910897 wikiPageExternalLink 1815.pdf.
- Q910897 wikiPageExternalLink histone_modification.html.
- Q910897 wikiPageExternalLink histonetable.pdf.
- Q910897 wikiPageWikiLink Q1036906.
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- Q910897 wikiPageWikiLink Q5773144.
- Q910897 wikiPageWikiLink Q7213749.
- Q910897 wikiPageWikiLink Q7430.
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- Q910897 wikiPageWikiLink Q874745.
- Q910897 wikiPageWikiLink Q898273.
- Q910897 wikiPageWikiLink Q910897.
- Q910897 wikiPageWikiLink Q911591.
- Q910897 comment "The histone code is a hypothesis that the transcription of genetic information encoded in DNA is in part regulated by chemical modifications to histone proteins, primarily on their unstructured ends. Together with similar modifications such as DNA methylation it is part of the epigenetic code. Histones associate with DNA to form nucleosomes, which themselves bundle to form chromatin fibers, which in turn make up the more familiar chromosome.".
- Q910897 label "Histone code".