Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q883112> ?p ?o }
- Q883112 subject Q7328102.
- Q883112 subject Q8420202.
- Q883112 abstract "Enzyme kinetics is the study of the chemical reactions that are catalysed by enzymes. In enzyme kinetics, the reaction rate is measured and the effects of varying the conditions of the reaction are investigated. Studying an enzyme's kinetics in this way can reveal the catalytic mechanism of this enzyme, its role in metabolism, how its activity is controlled, and how a drug or an agonist might inhibit the enzyme.Enzymes are usually protein molecules that manipulate other molecules — the enzymes' substrates. These target molecules bind to an enzyme's active site and are transformed into products through a series of steps known as the enzymatic mechanismE + S ⇄ ES ⇄ ES* ⇄ EP ⇄ E + PThese mechanisms can be divided into single-substrate and multiple-substrate mechanisms. Kinetic studies on enzymes that only bind one substrate, such as triosephosphate isomerase, aim to measure the affinity with which the enzyme binds this substrate and the turnover rate. Some other examples of enzymes are phosphofructokinase and hexokinase, both of which are important for cellular respiration (glycolysis).When enzymes bind multiple substrates, such as dihydrofolate reductase (shown right), enzyme kinetics can also show the sequence in which these substrates bind and the sequence in which products are released. An example of enzymes that bind a single substrate and release multiple products are proteases, which cleave one protein substrate into two polypeptide products. Others join two substrates together, such as DNA polymerase linking a nucleotide to DNA. Although these mechanisms are often a complex series of steps, there is typically one rate-determining step that determines the overall kinetics. This rate-determining step may be a chemical reaction or a conformational change of the enzyme or substrates, such as those involved in the release of product(s) from the enzyme.Knowledge of the enzyme's structure is helpful in interpreting kinetic data. For example, the structure can suggest how substrates and products bind during catalysis; what changes occur during the reaction; and even the role of particular amino acid residues in the mechanism. Some enzymes change shape significantly during the mechanism; in such cases, it is helpful to determine the enzyme structure with and without bound substrate analogues that do not undergo the enzymatic reaction.Not all biological catalysts are protein enzymes; RNA-based catalysts such as ribozymes and ribosomes are essential to many cellular functions, such as RNA splicing and translation. The main difference between ribozymes and enzymes is that RNA catalysts are composed of nucleotides, whereas enzymes are composed of amino acids. Ribozymes also perform a more limited set of reactions, although their reaction mechanisms and kinetics can be analysed and classified by the same methods.".
- Q883112 thumbnail EcDHFR_raytraced.png?width=300.
- Q883112 wikiPageExternalLink dNTP.html.
- Q883112 wikiPageExternalLink dhfr.html.
- Q883112 wikiPageExternalLink scriptFrame.html.
- Q883112 wikiPageExternalLink enzo.cmm.ki.si.
- Q883112 wikiPageExternalLink EzCatDB.
- Q883112 wikiPageExternalLink sabio.h-its.org.
- Q883112 wikiPageExternalLink enzyme.
- Q883112 wikiPageExternalLink contents.html.
- Q883112 wikiPageExternalLink 06_21_chymotrypsin.html.
- Q883112 wikiPageExternalLink www.brenda-enzymes.info.
- Q883112 wikiPageExternalLink kinetics.
- Q883112 wikiPageExternalLink MACiE.
- Q883112 wikiPageExternalLink model.swf.
- Q883112 wikiPageExternalLink explore.do?structureId=7DFR.
- Q883112 wikiPageExternalLink index.html.
- Q883112 wikiPageWikiLink Q102296.
- Q883112 wikiPageWikiLink Q10288948.
- Q883112 wikiPageWikiLink Q1057.
- Q883112 wikiPageWikiLink Q11053.
- Q883112 wikiPageWikiLink Q1128023.
- Q883112 wikiPageWikiLink Q11369.
- Q883112 wikiPageWikiLink Q11448.
- Q883112 wikiPageWikiLink Q11574.
- Q883112 wikiPageWikiLink Q118026.
- Q883112 wikiPageWikiLink Q11978.
- Q883112 wikiPageWikiLink Q12119506.
- Q883112 wikiPageWikiLink Q127450.
- Q883112 wikiPageWikiLink Q127920.
- Q883112 wikiPageWikiLink Q133895.
- Q883112 wikiPageWikiLink Q1386472.
- Q883112 wikiPageWikiLink Q14771739.
- Q883112 wikiPageWikiLink Q14819367.
- Q883112 wikiPageWikiLink Q14849060.
- Q883112 wikiPageWikiLink Q156333.
- Q883112 wikiPageWikiLink Q15712714.
- Q883112 wikiPageWikiLink Q17148629.
- Q883112 wikiPageWikiLink Q17156992.
- Q883112 wikiPageWikiLink Q171877.
- Q883112 wikiPageWikiLink Q178450.
- Q883112 wikiPageWikiLink Q179217.
- Q883112 wikiPageWikiLink Q179436.
- Q883112 wikiPageWikiLink Q180809.
- Q883112 wikiPageWikiLink Q183290.
- Q883112 wikiPageWikiLink Q185917.
- Q883112 wikiPageWikiLink Q189520.
- Q883112 wikiPageWikiLink Q190382.
- Q883112 wikiPageWikiLink Q191807.
- Q883112 wikiPageWikiLink Q191835.
- Q883112 wikiPageWikiLink Q196538.
- Q883112 wikiPageWikiLink Q205858.
- Q883112 wikiPageWikiLink Q206286.
- Q883112 wikiPageWikiLink Q208465.
- Q883112 wikiPageWikiLink Q209082.
- Q883112 wikiPageWikiLink Q212410.
- Q883112 wikiPageWikiLink Q2134627.
- Q883112 wikiPageWikiLink Q216906.
- Q883112 wikiPageWikiLink Q224450.
- Q883112 wikiPageWikiLink Q237218.
- Q883112 wikiPageWikiLink Q2448456.
- Q883112 wikiPageWikiLink Q249087.
- Q883112 wikiPageWikiLink Q25276.
- Q883112 wikiPageWikiLink Q2554020.
- Q883112 wikiPageWikiLink Q2642668.
- Q883112 wikiPageWikiLink Q26972.
- Q883112 wikiPageWikiLink Q2755024.
- Q883112 wikiPageWikiLink Q28745.
- Q883112 wikiPageWikiLink Q2902610.
- Q883112 wikiPageWikiLink Q2941663.
- Q883112 wikiPageWikiLink Q303568.
- Q883112 wikiPageWikiLink Q307302.
- Q883112 wikiPageWikiLink Q319325.
- Q883112 wikiPageWikiLink Q33293.
- Q883112 wikiPageWikiLink Q337217.
- Q883112 wikiPageWikiLink Q3394849.
- Q883112 wikiPageWikiLink Q3434574.
- Q883112 wikiPageWikiLink Q356257.
- Q883112 wikiPageWikiLink Q36534.
- Q883112 wikiPageWikiLink Q373406.
- Q883112 wikiPageWikiLink Q3799470.
- Q883112 wikiPageWikiLink Q383836.
- Q883112 wikiPageWikiLink Q38867.
- Q883112 wikiPageWikiLink Q3899816.
- Q883112 wikiPageWikiLink Q39572.
- Q883112 wikiPageWikiLink Q4066893.
- Q883112 wikiPageWikiLink Q407280.
- Q883112 wikiPageWikiLink Q407355.
- Q883112 wikiPageWikiLink Q407479.
- Q883112 wikiPageWikiLink Q407727.
- Q883112 wikiPageWikiLink Q408658.
- Q883112 wikiPageWikiLink Q40936.
- Q883112 wikiPageWikiLink Q412007.
- Q883112 wikiPageWikiLink Q412474.
- Q883112 wikiPageWikiLink Q415281.
- Q883112 wikiPageWikiLink Q416426.
- Q883112 wikiPageWikiLink Q419305.
- Q883112 wikiPageWikiLink Q420032.