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- Q7835406 subject Q4925926.
- Q7835406 subject Q7213749.
- Q7835406 subject Q7216294.
- Q7835406 abstract "Transvection is an epigenetic phenomenon that results from an interaction between an allele on one chromosome and the corresponding allele on the homologous chromosome. Transvection can lead to either gene activation or repression. It can also occur between nonallelic regions of the genome as well as regions of the genome that are not transcribed.The first observation of mitotic (i.e. non-meiotic) chromosome pairing was discovered via microscopy in 1908 by Nettie Stevens.Edward B. Lewis at Caltech discovered transvection at the bithorax complex in Drosophila in the 1950s. Since then, transvection has been observed at a number of additional loci in Drosophila, including white, decapentaplegic, eyes absent, vestigial, and yellow. As stated by Ed Lewis, "Operationally, transvection is occurring if the phenotype of a given genotype can be altered solely by disruption of somatic (or meiotic) pairing. Such disruption can generally be accomplished by introduction of a heterozygous rearrangement that disrupts pairing in the relevant region but has no position effect of its own on the phenotype" (cited by Ting Wu and Jim Morris 1999). Recently, pairing-mediated phenomena have been observed in species other than Drosophila, including mice, humans, plants, nematodes, insects, and fungi. In light of these findings, transvection may represent a potent and widespread form of gene regulation.Transvection appears to be dependent upon chromosome pairing. In some cases, if one allele is placed on a different chromosome by a translocation, transvection does not occur. Transvection can sometimes be restored in a translocation homozygote, where both alleles may once again be able to pair. Restoration of phenotype has been observed at bithorax, decapentaplegic, eyes absent, and vestigial, and with transgenes of white. In some cases, transvection between two alleles leads to intragenic complementation while disruption of transvection disrupts the complementation.Transvection is believed to occur through a variety of mechanisms. In one mechanism, the enhancers of one allele activate the promoter of a paired second allele. Other mechanisms include pairing-sensitive silencing and enhancer bypass of a chromatin insulator through pairing-mediated changes in gene structure.".
- Q7835406 wikiPageWikiLink Q133226.
- Q7835406 wikiPageWikiLink Q1471601.
- Q7835406 wikiPageWikiLink Q15989787.
- Q7835406 wikiPageWikiLink Q161562.
- Q7835406 wikiPageWikiLink Q162925.
- Q7835406 wikiPageWikiLink Q1780899.
- Q7835406 wikiPageWikiLink Q224093.
- Q7835406 wikiPageWikiLink Q26939.
- Q7835406 wikiPageWikiLink Q274123.
- Q7835406 wikiPageWikiLink Q2904898.
- Q7835406 wikiPageWikiLink Q312154.
- Q7835406 wikiPageWikiLink Q37748.
- Q7835406 wikiPageWikiLink Q433487.
- Q7835406 wikiPageWikiLink Q4925926.
- Q7835406 wikiPageWikiLink Q7187.
- Q7835406 wikiPageWikiLink Q7213749.
- Q7835406 wikiPageWikiLink Q7216294.
- Q7835406 wikiPageWikiLink Q80726.
- Q7835406 wikiPageWikiLink Q913367.
- Q7835406 wikiPageWikiLink Q916504.
- Q7835406 comment "Transvection is an epigenetic phenomenon that results from an interaction between an allele on one chromosome and the corresponding allele on the homologous chromosome. Transvection can lead to either gene activation or repression. It can also occur between nonallelic regions of the genome as well as regions of the genome that are not transcribed.The first observation of mitotic (i.e. non-meiotic) chromosome pairing was discovered via microscopy in 1908 by Nettie Stevens.Edward B.".
- Q7835406 label "Transvection (genetics)".