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- Q7833575 subject Q7213592.
- Q7833575 subject Q8680982.
- Q7833575 abstract "In molecular biology, trans-activating crRNA (tracrRNA) is a small trans-encoded RNA. It was first discovered in the human pathogen Streptococcus pyogenes. In bacteria and archaea, CRISPR/Cas (clustered, regularly interspaced short palindromic repeats/CRISPR-associated proteins) constitute an RNA-mediated defense system which protects against viruses and plasmids. This defensive pathway has three steps. First a copy of the invading nucleic acid is integrated into the CRISPR locus. Next, CRISPR RNAs (crRNAs) are transcribed from this CRISPR locus. The crRNAs are then incorporated into effector complexes, where the crRNA guides the complex to the invading nucleic acid and the Cas proteins degrade this nucleic acid. There are several pathways of CRISPR activation, one of which requires a tracrRNA which plays a role in the maturation of crRNA. TracrRNA is complementary to and base pairs with a pre-crRNA forming an RNA duplex. This is cleaved by RNase III, an RNA-specific ribonuclease, to form a crRNA/tracrRNA hybrid. This hybrid acts as a guide for the endonuclease Cas9, which cleaves the invading nucleic acid.".
- Q7833575 wikiPageExternalLink cite&retmode=ref&cmd=prlinks&id=22546939.
- Q7833575 wikiPageWikiLink Q106227.
- Q7833575 wikiPageWikiLink Q10872.
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- Q7833575 wikiPageWikiLink Q172778.
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- Q7833575 wikiPageWikiLink Q412563.
- Q7833575 wikiPageWikiLink Q415601.
- Q7833575 wikiPageWikiLink Q420927.
- Q7833575 wikiPageWikiLink Q422523.
- Q7833575 wikiPageWikiLink Q5.
- Q7833575 wikiPageWikiLink Q7213592.
- Q7833575 wikiPageWikiLink Q808.
- Q7833575 wikiPageWikiLink Q8680982.
- Q7833575 comment "In molecular biology, trans-activating crRNA (tracrRNA) is a small trans-encoded RNA. It was first discovered in the human pathogen Streptococcus pyogenes. In bacteria and archaea, CRISPR/Cas (clustered, regularly interspaced short palindromic repeats/CRISPR-associated proteins) constitute an RNA-mediated defense system which protects against viruses and plasmids. This defensive pathway has three steps. First a copy of the invading nucleic acid is integrated into the CRISPR locus.".
- Q7833575 label "Trans-activating crRNA".