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- Q7671336 subject Q7216147.
- Q7671336 subject Q9092838.
- Q7671336 abstract "Prior to the availability of sensitive TSH assays, thyrotropin releasing hormone (TRH)stimulation tests were relied upon for confirming and assessing the degree of suppressionin suspected hyperthyroidism. Typically, this stimulation test involves determining basalTSH levels and levels 15 to 30 minutes after an intravenous bolus of TRH. Normally,TSH would rise into the concentration range measurable with less sensitive TSH assays.Third generation TSH assays do not have thislimitation and thus TRH stimulation is generally not required when third generation TSHassays are used to assess degree of suppression. TRH-stimulation testing howevercontinues to be useful for the differential diagnosis of secondary (pituitary disorder)and tertiary (hypothalamic disorder) hypothyroidism. Patients with these conditionsappear to have physiologically inactive TSH in their circulation that is recognized byTSH assays to a degree such that they may yield misleading, "euthyroid" TSHresults. Use and Interpretation:• Helpful in diagnosis in patients with confusing TFTs. In primary hyperthyroidismTSH are low and TRH administration induces little or no change in TSH levels• In hypothyroidism due to end organ failure, administration of TRH produces aprompt increase in TSH• In hypothyroidism due to pituitary disease (secondary hypothyroidism)administration of TRH does not producean increase in TSH• In hypothyroidism due to hypothalamic disease (tertiary hypothyroidism), administration of TRH produces adelayed (60-120 minutes, rather than 15-30 minutes) increase in TSH".
- Q7671336 wikiPageExternalLink endo_thyroidfts.pdf.
- Q7671336 wikiPageWikiLink Q422294.
- Q7671336 wikiPageWikiLink Q7216147.
- Q7671336 wikiPageWikiLink Q9092838.
- Q7671336 comment "Prior to the availability of sensitive TSH assays, thyrotropin releasing hormone (TRH)stimulation tests were relied upon for confirming and assessing the degree of suppressionin suspected hyperthyroidism. Typically, this stimulation test involves determining basalTSH levels and levels 15 to 30 minutes after an intravenous bolus of TRH.".
- Q7671336 label "TRH stimulation test".