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- Q7542717 subject Q8754927.
- Q7542717 abstract "Small Cajal body-specific RNA 17 (also known as U12-22 scaRNA) is a type of small nuclear RNA which localises to the cajal bodies and proposed to guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.The complete human U12-22/U4-8 scaRNA is composed of two tandem C/D box domains (termed U12-22 and U4-8). The 5' and 3' C/D domains are predicted to guide the 2'O-ribose methylation of residue U22 in U12 and residue C8 in U4 snRNAs respectively. This family includes only the 5' C/D box domain (U12-22) as the 3' C/D box is represented by Small Cajal body specific RNA 18. The 3' C/D domain (U4-8) was also cloned previously by Darzacq and called U91. Both the doublet (U12-22/U4-8) and singlet (U4-8) forms of this snRNA have been purified from HeLa cells. The doublet form U12-22/U4-8 has been shown to localise to the nucleoplasm and is proposed to reside in the Cajal bodies whereas the U4-8 single domain appears to accumulate in the nucleolus. In humans the genomic location of U12-88/U4-8 is intergenic and the purified transcript has been shown to possess a methylated guanosine cap suggesting it is independently transcribed by RNA polymerase II.".
- Q7542717 thumbnail RF00492.jpg?width=300.
- Q7542717 wikiPageWikiLink Q14817956.
- Q7542717 wikiPageWikiLink Q15712714.
- Q7542717 wikiPageWikiLink Q17134281.
- Q7542717 wikiPageWikiLink Q17143795.
- Q7542717 wikiPageWikiLink Q19088.
- Q7542717 wikiPageWikiLink Q1995607.
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- Q7542717 wikiPageWikiLink Q2819374.
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- Q7542717 wikiPageWikiLink Q30869.
- Q7542717 wikiPageWikiLink Q3234345.
- Q7542717 wikiPageWikiLink Q3463539.
- Q7542717 wikiPageWikiLink Q390061.
- Q7542717 wikiPageWikiLink Q425326.
- Q7542717 wikiPageWikiLink Q4995178.
- Q7542717 wikiPageWikiLink Q583248.
- Q7542717 wikiPageWikiLink Q7187.
- Q7542717 wikiPageWikiLink Q7863597.
- Q7542717 wikiPageWikiLink Q847482.
- Q7542717 wikiPageWikiLink Q8754927.
- Q7542717 wikiPageWikiLink Q915868.
- Q7542717 comment "Small Cajal body-specific RNA 17 (also known as U12-22 scaRNA) is a type of small nuclear RNA which localises to the cajal bodies and proposed to guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.The complete human U12-22/U4-8 scaRNA is composed of two tandem C/D box domains (termed U12-22 and U4-8). The 5' and 3' C/D domains are predicted to guide the 2'O-ribose methylation of residue U22 in U12 and residue C8 in U4 snRNAs respectively.".
- Q7542717 label "Small Cajal body specific RNA 17".
- Q7542717 depiction RF00492.jpg.