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- Q7293428 subject Q8661849.
- Q7293428 abstract "Ranpirnase is a ribonuclease enzyme found in the oocytes of the Northern Leopard Frog (Rana pipiens). Ranpirnase is a member of the pancreatic ribonuclease (RNase A) protein superfamily and degrades RNA substrates with a sequence preference for uracil and guanine nucleotides. Along with amphinase, another leopard frog ribonuclease, ranpirnase has been studied as a potential cancer treatment due to its unusual mechanism of cytotoxicity tested against tumor cells.Ranpirnase was originally discovered by scientists at TamirBio, a biotechnology company (formerly Alfacell Corporation), where it was tested in clinical trials under the brand name Onconase. The mechanism of action of ranpirnase tumor-selective cytotoxicity has been attributed to the RNA interference pathway, potentially through cleaving siRNA molecules; to cleavage of transfer RNA; and to interference with the NF-κB pathway. Despite early indications of promise as a mesothelioma treatment, and an orphan drug status designation from the United States Food and Drug Administration in 2007, the Phase III clinical trial for this indication did not demonstrate statistical significance against primary endpoints.".
- Q7293428 thumbnail 2I5S.png?width=300.
- Q7293428 wikiPageWikiLink Q1077603.
- Q7293428 wikiPageWikiLink Q11053.
- Q7293428 wikiPageWikiLink Q12078.
- Q7293428 wikiPageWikiLink Q12119506.
- Q7293428 wikiPageWikiLink Q1216998.
- Q7293428 wikiPageWikiLink Q1340863.
- Q7293428 wikiPageWikiLink Q1367466.
- Q7293428 wikiPageWikiLink Q160398.
- Q7293428 wikiPageWikiLink Q169313.
- Q7293428 wikiPageWikiLink Q1819586.
- Q7293428 wikiPageWikiLink Q182990.
- Q7293428 wikiPageWikiLink Q201448.
- Q7293428 wikiPageWikiLink Q201993.
- Q7293428 wikiPageWikiLink Q203221.
- Q7293428 wikiPageWikiLink Q204711.
- Q7293428 wikiPageWikiLink Q246181.
- Q7293428 wikiPageWikiLink Q28745.
- Q7293428 wikiPageWikiLink Q30612.
- Q7293428 wikiPageWikiLink Q3246226.
- Q7293428 wikiPageWikiLink Q3271540.
- Q7293428 wikiPageWikiLink Q411114.
- Q7293428 wikiPageWikiLink Q422523.
- Q7293428 wikiPageWikiLink Q4748302.
- Q7293428 wikiPageWikiLink Q7108.
- Q7293428 wikiPageWikiLink Q7130419.
- Q7293428 wikiPageWikiLink Q7180990.
- Q7293428 wikiPageWikiLink Q8047.
- Q7293428 wikiPageWikiLink Q863908.
- Q7293428 wikiPageWikiLink Q8661849.
- Q7293428 comment "Ranpirnase is a ribonuclease enzyme found in the oocytes of the Northern Leopard Frog (Rana pipiens). Ranpirnase is a member of the pancreatic ribonuclease (RNase A) protein superfamily and degrades RNA substrates with a sequence preference for uracil and guanine nucleotides.".
- Q7293428 label "Ranpirnase".
- Q7293428 depiction 2I5S.png.