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- Q7277128 subject Q7213592.
- Q7277128 subject Q7216294.
- Q7277128 abstract "RNA-induced transcriptional silencing (RITS) is a form of RNA interference by which short RNA molecules - such as small interfering RNA (siRNA) - trigger the downregulation of transcription of a particular gene or genomic region. This is usually accomplished by posttranslational modification of histone tails (e.g. methylation of lysine 9 of histone H3) which target the genomic region for heterochromatin formation. The protein complex that binds to siRNAs and interacts with the methylated lysine 9 residue of histones H3 is the RITS complex.RITS was discovered in the fission yeast Schizosaccharomyces pombe, and has been shown to be involved in the initiation and spreading of heterochromatin in the mating-type region and in centromere formation. The RITS complex in S. pombe contains at least a piwi domain-containing RNase H-like argonaute, a chromodomain protein Chp1, and an argonaute interacting protein Tas3 which can also bind to Chp1, while heterochromatin formation has been shown to require at least argonaute and an RNA-dependent RNA polymerase. Loss of these genes in S. pombe results in abnormal heterochromatin organization and formation of the chromosome centromeres, resulting in slow or stalled anaphase during cell division.The maintenance of heterochromatin regions by RITS complexes has been described as a self-reinforcing feedback loop, in which RITS complexes stably bind the methylated histones of a heterochromatin region and induce co-transcriptional degradation of any nascent messenger RNA (mRNA) transcripts, which are then used as RNA-dependent RNA polymerase substrates to replenish the complement of siRNA molecules. Heterochromatin formation, but possibly not maintenance, is dependent on the ribonuclease protein dicer, which is used to generate the initial complement of siRNAs.The relevance of observations from fission yeast mating-type regions and centromeres to mammals is not clear, as some evidence suggests that heterochromatin maintenance in mammalian cells is independent of the components of the RNAi pathway.".
- Q7277128 wikiPageWikiLink Q11053.
- Q7277128 wikiPageWikiLink Q1242496.
- Q7277128 wikiPageWikiLink Q177900.
- Q7277128 wikiPageWikiLink Q18037154.
- Q7277128 wikiPageWikiLink Q183635.
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- Q7277128 wikiPageWikiLink Q203221.
- Q7277128 wikiPageWikiLink Q2044237.
- Q7277128 wikiPageWikiLink Q212739.
- Q7277128 wikiPageWikiLink Q22299157.
- Q7277128 wikiPageWikiLink Q2236682.
- Q7277128 wikiPageWikiLink Q2919111.
- Q7277128 wikiPageWikiLink Q3430179.
- Q7277128 wikiPageWikiLink Q36293.
- Q7277128 wikiPageWikiLink Q37748.
- Q7277128 wikiPageWikiLink Q413236.
- Q7277128 wikiPageWikiLink Q420927.
- Q7277128 wikiPageWikiLink Q422523.
- Q7277128 wikiPageWikiLink Q640013.
- Q7277128 wikiPageWikiLink Q7020.
- Q7277128 wikiPageWikiLink Q7187.
- Q7277128 wikiPageWikiLink Q7213592.
- Q7277128 wikiPageWikiLink Q7216294.
- Q7277128 wikiPageWikiLink Q7377.
- Q7277128 wikiPageWikiLink Q837783.
- Q7277128 comment "RNA-induced transcriptional silencing (RITS) is a form of RNA interference by which short RNA molecules - such as small interfering RNA (siRNA) - trigger the downregulation of transcription of a particular gene or genomic region. This is usually accomplished by posttranslational modification of histone tails (e.g. methylation of lysine 9 of histone H3) which target the genomic region for heterochromatin formation.".
- Q7277128 label "RNA-induced transcriptional silencing".