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- Q7265454 subject Q18924462.
- Q7265454 subject Q52319.
- Q7265454 subject Q6946436.
- Q7265454 subject Q7486806.
- Q7265454 subject Q8529670.
- Q7265454 subject Q8727262.
- Q7265454 abstract "QH-II-66 (QH-ii-066) is a sedative drug which is a benzodiazepine derivative. It produces some of the same effects as other benzodiazepines, but is much more selective than most other drugs of this class and so produces somewhat less sedation and ataxia than other related drugs such as diazepam and triazolam, although it still retains anticonvulsant effects.QH-ii-066 is a highly subtype-selective GABAA agonist which was designed to bind selectively to the α5 subtype of GABAA receptors.The α5 subtype (and to a lesser extent the α1 subtype) of GABAA are two of the most important targets in the brain that produce the effects of alcohol, and so one of the purposes for which QH-ii-066 was developed was to reproduce the GABAergic effects of alcohol separately from its other actions.QH-ii-066 replicates some of the effects of alcohol, such as sedation and ataxia, but does not increase appetite, as this effect seems to be produced by the α1 subtype of GABAA rather than α5. It is also interesting to note that the inverse agonist Ro15-4513, which blocks the α4 subtype of GABAA, reverses the effects of alcohol, suggesting that this subtype is also important in producing the subjective effects of alcohol intoxication.".
- Q7265454 casNumber "183239-39-6".
- Q7265454 iupacName "7-ethynyl-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one".
- Q7265454 pubchem "9838431".
- Q7265454 thumbnail QH-II-66.svg?width=300.
- Q7265454 wikiPageWikiLink Q154.
- Q7265454 wikiPageWikiLink Q1671731.
- Q7265454 wikiPageWikiLink Q18025082.
- Q7265454 wikiPageWikiLink Q18924462.
- Q7265454 wikiPageWikiLink Q210021.
- Q7265454 wikiPageWikiLink Q210402.
- Q7265454 wikiPageWikiLink Q213373.
- Q7265454 wikiPageWikiLink Q389934.
- Q7265454 wikiPageWikiLink Q412143.
- Q7265454 wikiPageWikiLink Q52319.
- Q7265454 wikiPageWikiLink Q576618.
- Q7265454 wikiPageWikiLink Q60147.
- Q7265454 wikiPageWikiLink Q6946436.
- Q7265454 wikiPageWikiLink Q7339199.
- Q7265454 wikiPageWikiLink Q7390120.
- Q7265454 wikiPageWikiLink Q7486806.
- Q7265454 wikiPageWikiLink Q83871.
- Q7265454 wikiPageWikiLink Q847705.
- Q7265454 wikiPageWikiLink Q8529670.
- Q7265454 wikiPageWikiLink Q8727262.
- Q7265454 casNumber "183239".
- Q7265454 iupacName "7".
- Q7265454 pubchem "9838431".
- Q7265454 type ChemicalSubstance.
- Q7265454 type Drug.
- Q7265454 type ChemicalObject.
- Q7265454 type Thing.
- Q7265454 type Q8386.
- Q7265454 comment "QH-II-66 (QH-ii-066) is a sedative drug which is a benzodiazepine derivative.".
- Q7265454 label "QH-II-66".
- Q7265454 depiction QH-II-66.svg.