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- Q7197544 subject Q13290357.
- Q7197544 subject Q8275351.
- Q7197544 abstract "Piquindone (Ro 22-1319) is an atypical antipsychotic with a tricyclic structure that was developed in the 1980s but was never marketed. It acts as a selective D2 receptor antagonist, though based on its effects profile its selectivity may be considered controversial. Unlike most other D2 receptor ligands, piquindone displays Na2+-dependent binding, a property it shares with tropapride, zetidoline, and metoclopramide.In clinical trials piquindone was found to possess moderate efficacy in treating positive symptoms of schizophrenia, and notably, was also modestly effective for negative symptoms, though this was just under statistical significance. Additionally, relative to haloperidol, it was found to possesses significantly fewer extrapyramidal symptoms and had a much lower propensity for inducing tardive dyskinesia, indicating its atypical nature. In addition to psychosis, piquindone has also been found to be effective in the treatment of Tourette's syndrome in numerous clinical studies.".
- Q7197544 atcPrefix "none".
- Q7197544 casNumber "78541-97-6".
- Q7197544 casSupplemental "83784-19-4 (hydrochloride)".
- Q7197544 fdaUniiCode "O1C9WXY65C".
- Q7197544 iupacName "(4aS,8aS)-3-ethyl-2,6-dimethyl-1,4a,5,6,7,8,8a,9-octahydro-4H-pyrrolo[2,3-g]isoquinolin-4-one".
- Q7197544 pubchem "121903".
- Q7197544 thumbnail Piquindone.png?width=300.
- Q7197544 wikiPageWikiLink Q13290357.
- Q7197544 wikiPageWikiLink Q1385411.
- Q7197544 wikiPageWikiLink Q15335165.
- Q7197544 wikiPageWikiLink Q1546328.
- Q7197544 wikiPageWikiLink Q170082.
- Q7197544 wikiPageWikiLink Q191779.
- Q7197544 wikiPageWikiLink Q251347.
- Q7197544 wikiPageWikiLink Q30612.
- Q7197544 wikiPageWikiLink Q410943.
- Q7197544 wikiPageWikiLink Q41112.
- Q7197544 wikiPageWikiLink Q420060.
- Q7197544 wikiPageWikiLink Q421095.
- Q7197544 wikiPageWikiLink Q4914025.
- Q7197544 wikiPageWikiLink Q500256.
- Q7197544 wikiPageWikiLink Q593166.
- Q7197544 wikiPageWikiLink Q6507061.
- Q7197544 wikiPageWikiLink Q658.
- Q7197544 wikiPageWikiLink Q6683616.
- Q7197544 wikiPageWikiLink Q758295.
- Q7197544 wikiPageWikiLink Q7841333.
- Q7197544 wikiPageWikiLink Q8275351.
- Q7197544 atcPrefix "none".
- Q7197544 casNumber "78541".
- Q7197544 casSupplemental "83784".
- Q7197544 iupacName "-3".
- Q7197544 pubchem "121903".
- Q7197544 unii "O1C9WXY65C".
- Q7197544 type ChemicalSubstance.
- Q7197544 type Drug.
- Q7197544 type ChemicalObject.
- Q7197544 type Thing.
- Q7197544 type Q8386.
- Q7197544 comment "Piquindone (Ro 22-1319) is an atypical antipsychotic with a tricyclic structure that was developed in the 1980s but was never marketed. It acts as a selective D2 receptor antagonist, though based on its effects profile its selectivity may be considered controversial.".
- Q7197544 label "Piquindone".
- Q7197544 depiction Piquindone.png.