Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q7187520> ?p ?o }
Showing triples 1 to 34 of
34
with 100 triples per page.
- Q7187520 subject Q6240946.
- Q7187520 abstract "Phospholipidosis is a lysosomal storage disorder characterized by the excess accumulation of phospholipids in tissues. Many cationic amphiphilic drugs, including anti-depressants, antianginal, antimalarial, and cholesterol-lowering agents, are reported to cause drug-induced phospholipidosis (DIPL) in animals and humans. The mechanisms of DIPL involve trapping or selective uptake of DIPL drugs within the lysosomes and acidic vesicles of affected cells. Drug trapping is followed by a gradual accumulation of drug-phospholipid complexes within the internal lysosomal membranes. The increase in undigested materials results in the abnormal accumulation of multi-lammellar bodies (myeloid bodies) in tissues.It is not possible to predict which tissues will be affected by DIPL in animals and humans. The use of specific in-vitro cell lines is not recommended as a means of gate-keeping for DIPL screening, only as part of an iterative process. An in-vivo screening platform, such as biomarker, is required for preclinical and clinical DIPL assessment.The traditional method to evaluate DIPL is visual confirmation of myeloid bodies in tissues by electron microscopy. Electron microscopy has limited utility to monitor DIPL in humans because of the invasive nature of acquiring patient tissue biopsy samples. A qualified biomarker of DIPL in the blood or urine is needed to provide a more routine, non-invasive, and cost effective means to monitor DIPL in the clinic.".
- Q7187520 wikiPageExternalLink kibron-pldscreen.
- Q7187520 wikiPageExternalLink Phospholipidosis.aspx.
- Q7187520 wikiPageWikiLink Q132560.
- Q7187520 wikiPageWikiLink Q1349821.
- Q7187520 wikiPageWikiLink Q1419931.
- Q7187520 wikiPageWikiLink Q1468324.
- Q7187520 wikiPageWikiLink Q165399.
- Q7187520 wikiPageWikiLink Q1758380.
- Q7187520 wikiPageWikiLink Q186915.
- Q7187520 wikiPageWikiLink Q189522.
- Q7187520 wikiPageWikiLink Q213511.
- Q7187520 wikiPageWikiLink Q251347.
- Q7187520 wikiPageWikiLink Q2553496.
- Q7187520 wikiPageWikiLink Q2736135.
- Q7187520 wikiPageWikiLink Q407972.
- Q7187520 wikiPageWikiLink Q408529.
- Q7187520 wikiPageWikiLink Q410061.
- Q7187520 wikiPageWikiLink Q412496.
- Q7187520 wikiPageWikiLink Q421094.
- Q7187520 wikiPageWikiLink Q422244.
- Q7187520 wikiPageWikiLink Q422438.
- Q7187520 wikiPageWikiLink Q422482.
- Q7187520 wikiPageWikiLink Q43656.
- Q7187520 wikiPageWikiLink Q58396.
- Q7187520 wikiPageWikiLink Q6240946.
- Q7187520 wikiPageWikiLink Q653924.
- Q7187520 wikiPageWikiLink Q692536.
- Q7187520 wikiPageWikiLink Q736270.
- Q7187520 wikiPageWikiLink Q824237.
- Q7187520 wikiPageWikiLink Q83330.
- Q7187520 comment "Phospholipidosis is a lysosomal storage disorder characterized by the excess accumulation of phospholipids in tissues. Many cationic amphiphilic drugs, including anti-depressants, antianginal, antimalarial, and cholesterol-lowering agents, are reported to cause drug-induced phospholipidosis (DIPL) in animals and humans. The mechanisms of DIPL involve trapping or selective uptake of DIPL drugs within the lysosomes and acidic vesicles of affected cells.".
- Q7187520 label "Phospholipidosis".