Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q7092091> ?p ?o }
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- Q7092091 subject Q7066600.
- Q7092091 subject Q7214254.
- Q7092091 subject Q7329501.
- Q7092091 abstract "Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with "cancer genomics". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.".
- Q7092091 thumbnail Overall_goals_of_oncogenomics.JPG?width=300.
- Q7092091 wikiPageExternalLink www.icgc.org.
- Q7092091 wikiPageExternalLink CGP.
- Q7092091 wikiPageExternalLink cgap.nci.nih.gov.
- Q7092091 wikiPageExternalLink rtcgd.abcc.ncifcrf.gov.
- Q7092091 wikiPageExternalLink oncology-suite.
- Q7092091 wikiPageExternalLink www.intogen.org.
- Q7092091 wikiPageExternalLink oncogenomics-explorer-overview.
- Q7092091 wikiPageExternalLink www.oncomine.org.
- Q7092091 wikiPageExternalLink www.progenetix.net.
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- Q7092091 wikiPageWikiLink Q7066600.
- Q7092091 wikiPageWikiLink Q7214254.
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- Q7092091 wikiPageWikiLink Q7329501.
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- Q7092091 type Thing.
- Q7092091 comment "Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with "cancer genomics". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation.".
- Q7092091 label "Oncogenomics".
- Q7092091 seeAlso Q5227418.
- Q7092091 depiction Overall_goals_of_oncogenomics.JPG.
