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- Q7049125 subject Q4925926.
- Q7049125 abstract "Non-allelic homologous recombination (NAHR) is a form of homologous recombination that occurs between two lengths of DNA that have high sequence similarity, but are not alleles.It usually occurs between sequences of DNA that have been previously duplicated through evolution, and therefore have low copy repeats (LCRs). These repeat elements typically range from 10–300 kb in length and share 95-97% sequence identity. During meiosis, LCRs can misalign and subsequent crossing-over can result in genetic rearrangement. When non-allelic homologous recombination occurs between different LCRs, deletions or further duplications of the DNA can occur. This can give rise to rare genetic disorders, caused by the loss or increased copy number of genes within the deleted or duplicated region. It can also contribute to the copy number variation seen in some gene clusters.As LCRs are often found in "hotspots" in the human genome, some chromosomal regions are particularly prone to NAHR. Recurrent rearrangements are nucleotide sequence variations found in multiple individuals, sharing a common size and location of break points. Therefore multiple patients may manifest with similar deletions or duplications, resulting in the description of genetic syndromes. Examples of these include NF1 microdeletion syndrome, 17q21.3 recurrent microdeletion syndrome or 3q29 microdeletion syndrome.".
- Q7049125 wikiPageWikiLink Q1501491.
- Q7049125 wikiPageWikiLink Q162925.
- Q7049125 wikiPageWikiLink Q179630.
- Q7049125 wikiPageWikiLink Q200779.
- Q7049125 wikiPageWikiLink Q2065945.
- Q7049125 wikiPageWikiLink Q211675.
- Q7049125 wikiPageWikiLink Q218447.
- Q7049125 wikiPageWikiLink Q244145.
- Q7049125 wikiPageWikiLink Q3716433.
- Q7049125 wikiPageWikiLink Q37748.
- Q7049125 wikiPageWikiLink Q4553565.
- Q7049125 wikiPageWikiLink Q4636618.
- Q7049125 wikiPageWikiLink Q4925926.
- Q7049125 wikiPageWikiLink Q656732.
- Q7049125 wikiPageWikiLink Q7430.
- Q7049125 wikiPageWikiLink Q7446270.
- Q7049125 wikiPageWikiLink Q746284.
- Q7049125 wikiPageWikiLink Q7616509.
- Q7049125 wikiPageWikiLink Q80726.
- Q7049125 comment "Non-allelic homologous recombination (NAHR) is a form of homologous recombination that occurs between two lengths of DNA that have high sequence similarity, but are not alleles.It usually occurs between sequences of DNA that have been previously duplicated through evolution, and therefore have low copy repeats (LCRs). These repeat elements typically range from 10–300 kb in length and share 95-97% sequence identity.".
- Q7049125 label "Non-allelic homologous recombination".