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- Q6714079 subject Q15301315.
- Q6714079 abstract "Mad2 (mitotic arrest deficient 2) is an essential spindle checkpoint protein. The spindle checkpoint system is a regulatory system that restrains progression through the metaphase-to-anaphase transition. The Mad2 gene was first identified in the yeast S. cerevisiae in a screen for genes which when mutated would confer sensitivity to microtubule poisons. The human orthologues of Mad2 (MAD2L1 and MAD2L2) were first cloned in a search for human cDNAs that would rescue the microtubule poison-sensitivity of a yeast strain in which a kinetochore binding protein was missing. The protein was shown to be present at unattached kinetochores and antibody inhibition studies demonstrated it was essential to execute a block in the metaphase-to-anaphase transition in response to the microtubule poison nocodazole. Subsequent cloning of the Xenopus laevis orthologue, facilitated by the sharing of the human sequence, allowed for the characterization of the mitotic checkpoint in egg extracts.".
- Q6714079 thumbnail MCC_on.png?width=300.
- Q6714079 wikiPageWikiLink Q15301315.
- Q6714079 wikiPageWikiLink Q17853888.
- Q6714079 wikiPageWikiLink Q17853927.
- Q6714079 wikiPageWikiLink Q17859720.
- Q6714079 wikiPageWikiLink Q18028772.
- Q6714079 wikiPageWikiLink Q18033896.
- Q6714079 wikiPageWikiLink Q18035401.
- Q6714079 wikiPageWikiLink Q188941.
- Q6714079 wikiPageWikiLink Q189933.
- Q6714079 wikiPageWikiLink Q22299157.
- Q6714079 wikiPageWikiLink Q2506092.
- Q6714079 wikiPageWikiLink Q310425.
- Q6714079 wikiPageWikiLink Q574427.
- Q6714079 wikiPageWikiLink Q719725.
- Q6714079 wikiPageWikiLink Q8054.
- Q6714079 wikiPageWikiLink Q837824.
- Q6714079 wikiPageWikiLink Q898483.
- Q6714079 wikiPageWikiLink Q9064829.
- Q6714079 wikiPageWikiLink Q908912.
- Q6714079 comment "Mad2 (mitotic arrest deficient 2) is an essential spindle checkpoint protein. The spindle checkpoint system is a regulatory system that restrains progression through the metaphase-to-anaphase transition. The Mad2 gene was first identified in the yeast S. cerevisiae in a screen for genes which when mutated would confer sensitivity to microtubule poisons.".
- Q6714079 label "Mad2".
- Q6714079 depiction MCC_on.png.