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- Q6667243 subject Q11721203.
- Q6667243 subject Q7036033.
- Q6667243 subject Q8612023.
- Q6667243 abstract "A Logan plot (or Logan graphical analysis) is a graphical analysis technique based on the compartment model that uses linear regression to analyze pharmacokinetics of tracers involving reversible uptake. It is mainly used for the evaluation of nuclear medicine imaging data after the injection of a labeled ligand that binds reversibly to specific receptor or enzyme.In conventional compartmental analysis, an iterative method is used to fit the individual model parameters in the solution of a compartmental model of specific configuration to the measurements with a measured plasma time-activity curve that serves as an forcing (input) function, and the binding of the tracer can then be described. Graphical analysis is a simplified method that transforms the model equations into a linear equation evaluated at multiple time points and provides fewer parameters (i.e., slope and intercept). Although the slope and the intercept can be interpreted in terms of a combination of model parameters if a compartmental model configuration is assumed, the graphical methods are independent of any specific model configuration. In case of irreversible tracers, certain fraction of the radioactivity is trapped in the tissue or the binding site during the course of the experiment, whereas reversible tracers show uptake and loss from all compartments throughout the study. The theoretical foundation of graphical analysis for irreversible tracers (also called Patlak graphical analysis or Patlak plot) was laid by Clifford Patlak and his colleagues at NIH. Based on the original work of Patlak, Jean Logan and her colleagues from Brookhaven National Laboratory extended the method to tracers with reversible kinetics.".
- Q6667243 wikiPageWikiLink Q10861030.
- Q6667243 wikiPageWikiLink Q11721203.
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- Q6667243 wikiPageWikiLink Q1332167.
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- Q6667243 wikiPageWikiLink Q6507061.
- Q6667243 wikiPageWikiLink Q6934435.
- Q6667243 wikiPageWikiLink Q7036033.
- Q6667243 wikiPageWikiLink Q7145078.
- Q6667243 wikiPageWikiLink Q8047.
- Q6667243 wikiPageWikiLink Q8612023.
- Q6667243 wikiPageWikiLink Q898254.
- Q6667243 wikiPageWikiLink Q898797.
- Q6667243 wikiPageWikiLink Q931309.
- Q6667243 comment "A Logan plot (or Logan graphical analysis) is a graphical analysis technique based on the compartment model that uses linear regression to analyze pharmacokinetics of tracers involving reversible uptake.".
- Q6667243 label "Logan plot".