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- Q6360598 subject Q8395757.
- Q6360598 subject Q8420225.
- Q6360598 abstract "Aminoglycoside-3'-phosphotransferase (APH(3')), also known as aminoglycoside kinase, is an enzyme that primarily catalyzes the addition of phosphate from ATP to the 3'-hydroxyl group of a 4,6-disubstituted aminoglycoside, such as kanamycin. However, APH(3') has also been found to phosphorylate at the 5'-hydroxyl group in 4,5-disubstituted aminoglycosides, which lack a 3'-hydroxyl group, and to diphosphorylate hydroxyl groups in aminoglycosides that have both 3'- and 5'-hydroxyl groups. Primarily positively charged at biological conditions, aminoglycosides bind to the negatively charged backbone of nucleic acids to disrupt protein synthesis, effectively inhibiting bacterial cell growth. APH(3') mediated phosphorylation of aminoglycosides effectively disrupts their mechanism of action, introducing a phosphate group that reduces their binding affinity due to steric hindrances and unfavorable electrostatic interactions. APH(3') is primarily found in certain species of gram-positive bacteria.This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:kanamycin 3'-O-phosphotransferase. This enzyme is also called neomycin-kanamycin phosphotransferase.".
- Q6360598 ecNumber "2.7.1.95".
- Q6360598 thumbnail APHStructure.png?width=300.
- Q6360598 wikiPageWikiLink Q104116.
- Q6360598 wikiPageWikiLink Q1230226.
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- Q6360598 wikiPageWikiLink Q8047.
- Q6360598 wikiPageWikiLink Q8066.
- Q6360598 wikiPageWikiLink Q80863.
- Q6360598 wikiPageWikiLink Q81163.
- Q6360598 wikiPageWikiLink Q82264.
- Q6360598 wikiPageWikiLink Q826582.
- Q6360598 wikiPageWikiLink Q8395757.
- Q6360598 wikiPageWikiLink Q8420225.
- Q6360598 wikiPageWikiLink Q857288.
- Q6360598 wikiPageWikiLink Q898238.
- Q6360598 wikiPageWikiLink Q899107.
- Q6360598 ecNumber "2.7".
- Q6360598 name "kanamycin kinase".
- Q6360598 type Biomolecule.
- Q6360598 type Enzyme.
- Q6360598 type Thing.
- Q6360598 type Q206229.
- Q6360598 type Q8047.
- Q6360598 comment "Aminoglycoside-3'-phosphotransferase (APH(3')), also known as aminoglycoside kinase, is an enzyme that primarily catalyzes the addition of phosphate from ATP to the 3'-hydroxyl group of a 4,6-disubstituted aminoglycoside, such as kanamycin. However, APH(3') has also been found to phosphorylate at the 5'-hydroxyl group in 4,5-disubstituted aminoglycosides, which lack a 3'-hydroxyl group, and to diphosphorylate hydroxyl groups in aminoglycosides that have both 3'- and 5'-hydroxyl groups.".
- Q6360598 label "Kanamycin kinase".
- Q6360598 depiction APHStructure.png.
- Q6360598 name "kanamycin kinase".