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- Q609809 subject Q7164711.
- Q609809 subject Q7204727.
- Q609809 abstract "A protein isoform is any of several different forms of the same protein. Different forms of a protein may be produced from very closely related gene duplicates—as 'same protein' or 'a protein' makes no sense for highly diverged paralogs that arose from a single ancestral gene that duplicated billions of years ago and subsequently diverged greatly in sequence, structure and functionality—or may arise from the same gene by alternative splicing. In older literature one can also encounter the use of the term isoform to describe alleles of the same gene, but currently the terms refers mostly to paralogous and alternatively spliced transcripts, not alleles.The discovery of isoforms could explain the small number of protein coding regions genes revealed by the human genome project: different proteins encoded by the same gene could increase the diversity of the proteome. Isoforms at the DNA level are readily characterized by cDNA transcript studies. Many human genes possess confirmed alternative splicing isoforms. It has been estimated that ~100,000 ESTs can be identified in humans. Isoforms at the protein level can manifest in deletion of whole domains or shorter loops, usually located on the surface of the protein.".
- Q609809 wikiPageExternalLink glossary=isoforms.
- Q609809 wikiPageExternalLink query.fcgi?cmd=Retrieve&db=mesh&list_uids=68020033&dopt=Full.
- Q609809 wikiPageWikiLink Q1129238.
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- Q609809 wikiPageWikiLink Q4688978.
- Q609809 wikiPageWikiLink Q5952725.
- Q609809 wikiPageWikiLink Q7164711.
- Q609809 wikiPageWikiLink Q7204727.
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- Q609809 wikiPageWikiLink Q860947.
- Q609809 wikiPageWikiLink Q898365.
- Q609809 comment "A protein isoform is any of several different forms of the same protein. Different forms of a protein may be produced from very closely related gene duplicates—as 'same protein' or 'a protein' makes no sense for highly diverged paralogs that arose from a single ancestral gene that duplicated billions of years ago and subsequently diverged greatly in sequence, structure and functionality—or may arise from the same gene by alternative splicing.".
- Q609809 label "Protein isoform".