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- Q5970086 subject Q19692067.
- Q5970086 subject Q8248910.
- Q5970086 subject Q8297722.
- Q5970086 subject Q8919936.
- Q5970086 abstract "IDRA-21 is an ampakine drug and a benzothiadiazine derivative. IDRA-21 is a chiral molecule, with (+)-IDRA-21 being the active form.IDRA-21 shows nootropic effects in animal studies, significantly improving learning and memory. It is around 10–30 times more potent than aniracetam in reversing cognitive deficits induced by alprazolam or scopolamine, and produces sustained effects lasting for up to 48 hours after a single dose. The mechanism for this action is thought to be through promoting the induction of long-term potentiation between synapses in the brain.IDRA-21 does not produce neurotoxicity under normal conditions, although it may worsen neuronal damage following global ischemia after stroke or seizures.In comparison to the benzoylpiperidine derived ampakine drugs, IDRA-21 was more potent than CX-516, but less potent than CX-546. Newer benzothiadiazide derivatives with greatly increased potency compared to IDRA-21 have been developed, but these have not been researched to the same extent, with the benzoylpiperidine and benzoylpyrrolidine CX-series of drugs being favoured for clinical development, most likely due to more favourable toxicity profiles at high doses.".
- Q5970086 casNumber "22503-72-6".
- Q5970086 iupacName "7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide".
- Q5970086 pubchem "3688".
- Q5970086 thumbnail IDRA-21.svg?width=300.
- Q5970086 wikiPageWikiLink Q1805481.
- Q5970086 wikiPageWikiLink Q19692067.
- Q5970086 wikiPageWikiLink Q2495337.
- Q5970086 wikiPageWikiLink Q319877.
- Q5970086 wikiPageWikiLink Q337188.
- Q5970086 wikiPageWikiLink Q417630.
- Q5970086 wikiPageWikiLink Q420009.
- Q5970086 wikiPageWikiLink Q4890804.
- Q5970086 wikiPageWikiLink Q5014874.
- Q5970086 wikiPageWikiLink Q5014875.
- Q5970086 wikiPageWikiLink Q5552687.
- Q5970086 wikiPageWikiLink Q742487.
- Q5970086 wikiPageWikiLink Q8248910.
- Q5970086 wikiPageWikiLink Q8297722.
- Q5970086 wikiPageWikiLink Q8919936.
- Q5970086 casNumber "22503".
- Q5970086 iupacName "7".
- Q5970086 pubchem "3688".
- Q5970086 type ChemicalSubstance.
- Q5970086 type Drug.
- Q5970086 type ChemicalObject.
- Q5970086 type Thing.
- Q5970086 type Q8386.
- Q5970086 comment "IDRA-21 is an ampakine drug and a benzothiadiazine derivative. IDRA-21 is a chiral molecule, with (+)-IDRA-21 being the active form.IDRA-21 shows nootropic effects in animal studies, significantly improving learning and memory. It is around 10–30 times more potent than aniracetam in reversing cognitive deficits induced by alprazolam or scopolamine, and produces sustained effects lasting for up to 48 hours after a single dose.".
- Q5970086 label "IDRA-21".
- Q5970086 depiction IDRA-21.svg.