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- Q5631166 subject Q8788410.
- Q5631166 abstract "HMR 1883 (1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3 methylthiourea) and its sodium salt HMR 1098, are experimental anti-arrhythmic drugs classified as sulfonylthiourea compounds. Their main purpose is to treat ventricular fibrillation caused by myocardial ischemia. They were synthesized via structural modifications to glibenclamide, an antidiabetic drug. Both HMR 1883 and glibenclamide act by inactivating the ATP-sensitive potassium channels (KATP) responsible for potassium efflux. Unlike glibenclamide, HMR 1883 has been suggested to target selectively the Kir6.2/SUR2A KATP subtype, found mostly in the membranes of cardiac cells. However, data showing that HMR 1098 inhibits the Kir6.2/SUR1 KATP subtype found in insulin-secreting pancreatic beta cells challenges this view.".
- Q5631166 wikiPageWikiLink Q12370.
- Q5631166 wikiPageWikiLink Q241549.
- Q5631166 wikiPageWikiLink Q29548.
- Q5631166 wikiPageWikiLink Q411691.
- Q5631166 wikiPageWikiLink Q420626.
- Q5631166 wikiPageWikiLink Q575062.
- Q5631166 wikiPageWikiLink Q80863.
- Q5631166 wikiPageWikiLink Q844935.
- Q5631166 wikiPageWikiLink Q848662.
- Q5631166 wikiPageWikiLink Q8788410.
- Q5631166 comment "HMR 1883 (1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3 methylthiourea) and its sodium salt HMR 1098, are experimental anti-arrhythmic drugs classified as sulfonylthiourea compounds. Their main purpose is to treat ventricular fibrillation caused by myocardial ischemia. They were synthesized via structural modifications to glibenclamide, an antidiabetic drug.".
- Q5631166 label "HMR 1883".