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- Q5630684 subject Q7233066.
- Q5630684 abstract "HMB-45 is a monoclonal antibody that reacts against an antigen present in melanocytic tumors such as melanomas, and stands for human melanoma black 45. It is used in anatomic pathology as a marker for such tumors. The specific antigen recognized by HMB-45 is now known as Pmel 17.HMB-45 was discovered by Drs. Allen M. Gown and Arthur M. Vogel in 1986. The antibody was generated to an extract of melanoma. It reacts positively against melanocytic tumors but not other tumors, thus demonstrating specificity and sensitivity.In a study to determine diagnostic usefulness of specific antibodies used to identify melanoma, HMB-45 had a 92% sensitivity when used to identify melanoma. The antibody also reacts positively against junctional nevus cells and fetal melanocytes.Despite this relatively high sensitivity—HMB-45 does have its drawbacks. HMB-45 can be detected in only 50-70% of melanomas. HMB-45 does not react well against intradermal nevi, normal adult melanocytes, spindle cell melanomas and desmoplastic melanomas. HMB-45 is nonreactive with almost all non-melanoma human malignancies, with the exception of rare tumors showing evidence of melanogenesis (e.g., pigmented schwannoma, clear cell sarcoma) or tumors associated with tuberous sclerosis complex (angiomyolipoma and lymphangiomyoma).StorageHMB-45 should be stored at 4 degree Celsius. At 4 degrees Celsius the antibody will be stable for up to 2 months without any loss of quality. For best results it should be used before the expiration date.Other AntibodiesWhen conducting an immunocytochemical studies to identify melanoma for scientific or clinical studies, scientist and medical professionals can also use S-100, Melan-A, Tyrosinase, and Mitf to identify tumors.".
- Q5630684 wikiPageExternalLink index.html?datasheet=787.
- Q5630684 wikiPageExternalLink 12472287.
- Q5630684 wikiPageExternalLink PMEL17-SILV-Antibody-HMB45_NBP2-29418.html.
- Q5630684 wikiPageExternalLink datasheet-59305-melanoma-marker-hmb45-antibody.html.
- Q5630684 wikiPageWikiLink Q1216998.
- Q5630684 wikiPageWikiLink Q1362721.
- Q5630684 wikiPageWikiLink Q17098359.
- Q5630684 wikiPageWikiLink Q180614.
- Q5630684 wikiPageWikiLink Q223911.
- Q5630684 wikiPageWikiLink Q247101.
- Q5630684 wikiPageWikiLink Q369148.
- Q5630684 wikiPageWikiLink Q422248.
- Q5630684 wikiPageWikiLink Q4664502.
- Q5630684 wikiPageWikiLink Q539681.
- Q5630684 wikiPageWikiLink Q683455.
- Q5630684 wikiPageWikiLink Q692077.
- Q5630684 wikiPageWikiLink Q7233066.
- Q5630684 comment "HMB-45 is a monoclonal antibody that reacts against an antigen present in melanocytic tumors such as melanomas, and stands for human melanoma black 45. It is used in anatomic pathology as a marker for such tumors. The specific antigen recognized by HMB-45 is now known as Pmel 17.HMB-45 was discovered by Drs. Allen M. Gown and Arthur M. Vogel in 1986. The antibody was generated to an extract of melanoma.".
- Q5630684 label "HMB-45".