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- Q5533487 subject Q18176218.
- Q5533487 subject Q18673047.
- Q5533487 subject Q6362678.
- Q5533487 subject Q7029000.
- Q5533487 subject Q7214225.
- Q5533487 abstract "The 2000s witnessed an explosion of genome sequencing and mapping in evolutionarily diverse species. While full genome sequencing of mammals is rapidly progressing, the ability to assemble and align orthologous whole chromosomal regions from more than a few species is not yet possible. The intense focus on the building of comparative maps for domestic (dogs and cats), laboratory (mice and rats) and agricultural (cattle) animals has traditionally been used to understand the underlying basis of disease-related and healthy phenotypes. These maps also provide an unprecedented opportunity to use multispecies analysis as a tool to infer karyotype evolution. Comparative chromosome painting and related techniques are very powerful approaches in comparative genome studies. Homologies can be identified with high accuracy using molecularly defined DNA probes for fluorescence in situ hybridization (FISH) on chromosomes of different species. Chromosome painting data are now available for members of nearly all mammalian orders. It was found that in most orders, there are species with rates of chromosome evolution that can be considered as 'default' rates. It needs to be noted that the number of rearrangements that have become fixed in evolutionary history seems relatively low, due to 180 million years of the mammalian radiation. Thus a record of the history of karyotype changes that have occurred during evolution have been attained through comparative chromosome maps.".
- Q5533487 thumbnail An_evolutionary_tree_of_mammals.jpeg?width=300.
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- Q5533487 comment "The 2000s witnessed an explosion of genome sequencing and mapping in evolutionarily diverse species. While full genome sequencing of mammals is rapidly progressing, the ability to assemble and align orthologous whole chromosomal regions from more than a few species is not yet possible.".
- Q5533487 label "Genome diversity and karyotype evolution of mammals".
- Q5533487 depiction An_evolutionary_tree_of_mammals.jpeg.