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- Q5502127 subject Q9694863.
- Q5502127 abstract "The French Flag Model is a conceptual definition of a morphogen, described by Lewis Wolpert in the 1960s. A morphogen is rigorously defined as a signaling molecule that acts directly on cells (not through serial induction) to produce specific cellular responses dependent on morphogen concentration. During early development, morphogen gradients generate different cell types in distinct spatial order.In the French flag model, the French flag is used to represent the effect of a morphogen on cell differentiation: a morphogen affects cell states based on concentration, these states are represented by the different colors of the French flag: high concentrations activate a "blue" gene, lower concentrations activate a "white" gene, with "red" serving as the default state in cells below the necessary concentration threshold.The French Flag model was championed by the leading Drosophila biologist, Peter Lawrence. Christiane Nüsslein-Volhard identified the first morphogen, Bicoid, one of the transcription factors present in a gradient in the Drosophila syncytial embryo. Two labs, that of Gary Struhl and that of Stephen Cohen, then demonstrated that a secreted signaling protein, Decapentaplegic (the Drosophila homologue of Transforming Growth Factor Beta), acted as a morphogen during later stages of Drosophila development. substance governing the pattern of tissue development and, in particular, the positions of the various specialized cell types within a tissue. It spreads from a localized source and forms a concentration gradient across a developing tissue.Well-known morphogens include: Decapentaplegic / Transforming growth factor beta, Hedgehog / Sonic Hedgehog, Wingless / Wnt, Epidermal growth factor, and Fibroblast growth factor.Some of the earliest and best-studied morphogens are transcription factors that diffuse within early Drosophila melanogaster (fruit fly) embryos. However, most morphogens are secreted proteins that signal between cells.Morphogens are defined conceptually, not chemically, so simple chemicals such as retinoic acid may also act as morphogens.".
- Q5502127 thumbnail Concs.gif?width=300.
- Q5502127 wikiPageExternalLink ALifeXIflag.
- Q5502127 wikiPageExternalLink www.flybase.org.
- Q5502127 wikiPageExternalLink 1aahome.htm.
- Q5502127 wikiPageExternalLink query.fcgi?db=OMIM.
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- Q5502127 wikiPageWikiLink Q903852.
- Q5502127 wikiPageWikiLink Q9694863.
- Q5502127 wikiPageWikiLink Q976767.
- Q5502127 comment "The French Flag Model is a conceptual definition of a morphogen, described by Lewis Wolpert in the 1960s. A morphogen is rigorously defined as a signaling molecule that acts directly on cells (not through serial induction) to produce specific cellular responses dependent on morphogen concentration.".
- Q5502127 label "French flag model".
- Q5502127 depiction Concs.gif.