Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q5473321> ?p ?o }
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- Q5473321 subject Q18924462.
- Q5473321 subject Q6946436.
- Q5473321 subject Q7486806.
- Q5473321 subject Q8919936.
- Q5473321 abstract "Fosazepam is a drug which is a benzodiazepine derivative; it is a water soluble derivative of diazepam. It has sedative and anxiolytic effects, and is a derivative of diazepam which has been substituted with a dimethylphosphoryl group to improve solubility in water.Fosazepam has similar effects on sleep as other benzodiazepines. In a clinical trial it was reported that fosazepam to lead to increased sleep duration with less broken sleep but sleep quality was worsened with suppressed deep sleep and increased light sleep. Adverse effects included feelings of impaired morning vitality and upon discontinuing the drug benzodiazepine withdrawal symptoms of anxiety, impaired concentration and impaired morning vitality were experienced. Another clinical trial also found worsening of sleep while on benzodiazepines as well as during withdrawal with suppression of deep sleep stages including REM sleep, with increased light sleep upon withdrawal. The main metabolites of fosazepam are 3-hydroxyfosazepam and the active metabolite desmethyldiazepam which has a very long elimination half-life of about 3 days. Tolerance to the hypnotic effects of fosazepam starts to develop after about 7 days of use. Due to the very long elimination half-life of the active metabolite of fosazepam it is not recommended for use as a hypnotic. The main pharmacological effects of fosazepam may be due to its metabolite nordiazepam (desmethyldiazepam), rather than the parent drug. The long-acting active metabolite nordazepam can cause extended sedative effects at high doses or with prolonged use, and may produce residual sedation upon awakening.Fosazepam is of relatively low potency compared to other benzodiazepine derivatives, with a 100 mg dose of fosazepam equivalent to 10 mg of nitrazepam. 60 mg of fosazepam has also been estimated to be equivalent to about 5–10 mg of diazepam. Fosazepam has similar effects to nitrazepam, but with a shorter duration of action and less tendency to cause over sedation, motor-impairment, amnesia, rebound insomnia, and morning grogginess.".
- Q5473321 atcPrefix "none".
- Q5473321 casNumber "35322-07-7".
- Q5473321 fdaUniiCode "13AK3H33SG".
- Q5473321 iupacName "7-chloro-1-(dimethylphosphorylmethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one".
- Q5473321 pubchem "37114".
- Q5473321 thumbnail Fosazepam.svg?width=300.
- Q5473321 wikiPageWikiLink Q1425425.
- Q5473321 wikiPageWikiLink Q154430.
- Q5473321 wikiPageWikiLink Q170731.
- Q5473321 wikiPageWikiLink Q18924462.
- Q5473321 wikiPageWikiLink Q210402.
- Q5473321 wikiPageWikiLink Q211402.
- Q5473321 wikiPageWikiLink Q3180288.
- Q5473321 wikiPageWikiLink Q407595.
- Q5473321 wikiPageWikiLink Q410078.
- Q5473321 wikiPageWikiLink Q4677569.
- Q5473321 wikiPageWikiLink Q498902.
- Q5473321 wikiPageWikiLink Q6119887.
- Q5473321 wikiPageWikiLink Q62903.
- Q5473321 wikiPageWikiLink Q62962.
- Q5473321 wikiPageWikiLink Q686886.
- Q5473321 wikiPageWikiLink Q6946436.
- Q5473321 wikiPageWikiLink Q7486806.
- Q5473321 wikiPageWikiLink Q83871.
- Q5473321 wikiPageWikiLink Q847705.
- Q5473321 wikiPageWikiLink Q8919936.
- Q5473321 atcPrefix "none".
- Q5473321 casNumber "35322".
- Q5473321 iupacName "7".
- Q5473321 pubchem "37114".
- Q5473321 unii "13".
- Q5473321 type ChemicalSubstance.
- Q5473321 type Drug.
- Q5473321 type ChemicalObject.
- Q5473321 type Thing.
- Q5473321 type Q8386.
- Q5473321 comment "Fosazepam is a drug which is a benzodiazepine derivative; it is a water soluble derivative of diazepam. It has sedative and anxiolytic effects, and is a derivative of diazepam which has been substituted with a dimethylphosphoryl group to improve solubility in water.Fosazepam has similar effects on sleep as other benzodiazepines.".
- Q5473321 label "Fosazepam".
- Q5473321 depiction Fosazepam.svg.