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- Q5463029 subject Q6373125.
- Q5463029 subject Q7217019.
- Q5463029 subject Q7217021.
- Q5463029 abstract "Flux balance analysis (FBA) is a mathematical method for simulating metabolism in genome-scale reconstructions of metabolic networks. In comparison to traditional methods of modeling, FBA is less intensive in terms of the input data required for constructing the model. Simulations performed using FBA are computationally inexpensive and can calculate steady-state metabolic fluxes for large models (over 2000 reactions) in a few seconds on modern personal computers.FBA finds applications in bioprocess engineering to systematically identify modifications to the metabolic networks of microbes used in fermentation processes that improve product yields of industrially important chemicals such as ethanol and succinic acid. It has also been used for the identification of putative drug targets in cancer and pathogens, rational design of culture media, and more recently host–pathogen interactions. The results of FBA can be visualized using flux maps similar to the image on the right, which illustrates the steady-state fluxes carried by reactions in glycolysis. The thickness of the arrows is proportional to the flux through the reaction.FBA formalizes the system of equations describing the concentration changes in a metabolic network as the dot product of a matrix of the stoichiometric coefficients (the stoichiometric matrix S) and the vector v of the unsolved fluxes. The right-hand side of the dot product is a vector of zeros representing the system at steady state. Linear programming is then used to calculate a solution of fluxes corresponding to the steady state.".
- Q5463029 thumbnail Results_of_FBA.png?width=300.
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- Q5463029 wikiPageWikiLink Q6373125.
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- Q5463029 wikiPageWikiLink Q7217019.
- Q5463029 wikiPageWikiLink Q7217021.
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- Q5463029 comment "Flux balance analysis (FBA) is a mathematical method for simulating metabolism in genome-scale reconstructions of metabolic networks. In comparison to traditional methods of modeling, FBA is less intensive in terms of the input data required for constructing the model.".
- Q5463029 label "Flux balance analysis".
- Q5463029 depiction Results_of_FBA.png.