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- Q5418212 subject Q8680982.
- Q5418212 abstract "DLX6 antisense RNA 1 (DLX6-AS1) (Evf-1 (Embryonic ventral forebrain-1)) is a developmentally-regulated long non-coding RNA. In rats, it is expressed in neurons in the subventricular zone of the developing forebrain. Its expression is linked to that of the Shh (sonic hedgehog) and DLX families of genes, which are important in ventral forebrain and craniofacial development. An alternatively spliced form of DLX6-AS1, DLX6-AS2, forms a stable complex with the Dlx-2 protein. This complex activates transcription of Dlx-5 and Dlx-6.DLX6-AS2 regulates gene expression in a region of the brain which produces GABAergic interneurons during development. It is involved in the signaling pathway and works in conjunction with DLX homeodomain proteins to increase the effectiveness of the Dlx5/6 enhancer element within neural stem cells. The interneurons are found in the hippocampus of the adult brain, an area responsible for learning and memory.GABAergic interneurons have been implicated in a number of psychiatric disorders including autism, schizophrenia and epilepsy; as DLX6-AS2 controls the development of these neurones, it has been subject to studies regarding the causation of these disorders.DLX6-AS2 is the first known long non-coding RNA to be involved in organogenesis.".
- Q5418212 thumbnail Evf2-ss-cons.png?width=300.
- Q5418212 wikiPageExternalLink pmidlookup?view=long&pmid=9811591.
- Q5418212 wikiPageExternalLink 151.
- Q5418212 wikiPageExternalLink pmidlookup?view=long&pmid=11731473.
- Q5418212 wikiPageWikiLink Q12135.
- Q5418212 wikiPageWikiLink Q133500.
- Q5418212 wikiPageWikiLink Q14860072.
- Q5418212 wikiPageWikiLink Q1500732.
- Q5418212 wikiPageWikiLink Q15087973.
- Q5418212 wikiPageWikiLink Q210021.
- Q5418212 wikiPageWikiLink Q26972.
- Q5418212 wikiPageWikiLink Q36396.
- Q5418212 wikiPageWikiLink Q38404.
- Q5418212 wikiPageWikiLink Q41112.
- Q5418212 wikiPageWikiLink Q41571.
- Q5418212 wikiPageWikiLink Q43054.
- Q5418212 wikiPageWikiLink Q48196.
- Q5418212 wikiPageWikiLink Q48360.
- Q5418212 wikiPageWikiLink Q492.
- Q5418212 wikiPageWikiLink Q507027.
- Q5418212 wikiPageWikiLink Q5090604.
- Q5418212 wikiPageWikiLink Q5182134.
- Q5418212 wikiPageWikiLink Q54063.
- Q5418212 wikiPageWikiLink Q7187.
- Q5418212 wikiPageWikiLink Q7377.
- Q5418212 wikiPageWikiLink Q8680982.
- Q5418212 wikiPageWikiLink Q898769.
- Q5418212 wikiPageWikiLink Q958938.
- Q5418212 comment "DLX6 antisense RNA 1 (DLX6-AS1) (Evf-1 (Embryonic ventral forebrain-1)) is a developmentally-regulated long non-coding RNA. In rats, it is expressed in neurons in the subventricular zone of the developing forebrain. Its expression is linked to that of the Shh (sonic hedgehog) and DLX families of genes, which are important in ventral forebrain and craniofacial development. An alternatively spliced form of DLX6-AS1, DLX6-AS2, forms a stable complex with the Dlx-2 protein.".
- Q5418212 label "DLX6-AS1".
- Q5418212 depiction Evf2-ss-cons.png.