Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q5280075> ?p ?o }
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- Q5280075 subject Q6938881.
- Q5280075 subject Q8645495.
- Q5280075 subject Q8729038.
- Q5280075 subject Q8887197.
- Q5280075 subject Q9056368.
- Q5280075 abstract "Dipropanoylmorphine (Dipropionylmorphine in U.S. English) is an opiate derivative, the 3,6-dipropanoyl ester of morphine. It was developed in 1972 as an analgesic. It is rarely used in some countries for the relief of severe pain such as that caused by terminal cancer, as an alternative to diamorphine (heroin) and morphine. The drug was first synthesised circa or about 1875 in Great Britain along with many other esters of morphine, all of which were shelved at the time, some of which were later developed such as heroin (1898), acetylpropionylmorphine (1923), dibenzoylmorphine (1900 and/or 1924), and so on. The name of this drug is also given as 3,6-dipropanoylmorphine and its 6-mono-acetylated homologue is also a longer-acting heroin-like drug, as are 3,6-diformylmorphine and 6-formylmorphine.Dipropanoylmorphine, though rarely used, is considered to be a safer and less addictive alternative to morphine. Studies and clinical trials comparing dipropanoylmorphine to morphine have produced results that indicate the incidence of side-effects are far more common with morphine. Respiratory depression, euphoria, excessive sedation and somnolence (so-called 'nodding' by recreational opioid users), constipation, miosis (pinpoint pupils), nausea, bradycardia, behavioral disturbances, and severe physical and psychological dependence on morphine is more likely with the use of morphine versus dipropanoylmorphine.Dipropanoylmorphine is slightly slower acting than diamorphine and morphine, but longer lasting, and is slightly more potent by weight due to its higher lipophilicity. Side effects are generally relatively mild for an opioid with a similar profile to morphine/heroin and typical of other opioids. The most common side effects associated with dipropanoylmorphine are itching, nausea and respiratory depression.Dipropanoylmorphine is prepared by reacting morphine with propionic anhydride, in an analogous manner to how heroin is produced by reacting morphine with acetic anhydride.While acetic anhydride is a restricted chemical around the world due to its potential uses in making heroin from morphine for the illicit market, it is used in vast amounts by the chemical industry for the manufacture of drugs such as aspirin. Propanoic anhydride however is much less widely used. Although it is used in the manufacture of a range of pharmaceuticals, none of these are produced in nearly as large quantities, and sales of propanoic anhydride in quantities larger than one gram must be reported in many countries because of its potential use in making fentanyl type synthetic opiates.".
- Q5280075 atcPrefix "none".
- Q5280075 casNumber "10589-79-4".
- Q5280075 iupacName "(5α,6α)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan 3,6-dipropionate".
- Q5280075 pubchem "165894".
- Q5280075 thumbnail Dipropanoylmorphine.svg?width=300.
- Q5280075 wikiPageWikiLink Q101487.
- Q5280075 wikiPageWikiLink Q12078.
- Q5280075 wikiPageWikiLink Q1641494.
- Q5280075 wikiPageWikiLink Q173235.
- Q5280075 wikiPageWikiLink Q18216.
- Q5280075 wikiPageWikiLink Q186889.
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- Q5280075 wikiPageWikiLink Q2026938.
- Q5280075 wikiPageWikiLink Q203994.
- Q5280075 wikiPageWikiLink Q217111.
- Q5280075 wikiPageWikiLink Q407541.
- Q5280075 wikiPageWikiLink Q407775.
- Q5280075 wikiPageWikiLink Q418066.
- Q5280075 wikiPageWikiLink Q427523.
- Q5280075 wikiPageWikiLink Q4673318.
- Q5280075 wikiPageWikiLink Q5272259.
- Q5280075 wikiPageWikiLink Q596899.
- Q5280075 wikiPageWikiLink Q60168.
- Q5280075 wikiPageWikiLink Q6938881.
- Q5280075 wikiPageWikiLink Q81225.
- Q5280075 wikiPageWikiLink Q81938.
- Q5280075 wikiPageWikiLink Q8645495.
- Q5280075 wikiPageWikiLink Q8729038.
- Q5280075 wikiPageWikiLink Q8887197.
- Q5280075 wikiPageWikiLink Q9056368.
- Q5280075 atcPrefix "none".
- Q5280075 casNumber "10589".
- Q5280075 iupacName "-78".
- Q5280075 pubchem "165894".
- Q5280075 type ChemicalSubstance.
- Q5280075 type Drug.
- Q5280075 type ChemicalObject.
- Q5280075 type Thing.
- Q5280075 type Q8386.
- Q5280075 comment "Dipropanoylmorphine (Dipropionylmorphine in U.S. English) is an opiate derivative, the 3,6-dipropanoyl ester of morphine. It was developed in 1972 as an analgesic. It is rarely used in some countries for the relief of severe pain such as that caused by terminal cancer, as an alternative to diamorphine (heroin) and morphine.".
- Q5280075 label "Dipropanoylmorphine".
- Q5280075 depiction Dipropanoylmorphine.svg.
