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- Q5205903 subject Q52376.
- Q5205903 subject Q8732555.
- Q5205903 subject Q8919936.
- Q5205903 abstract "DOV-102,677 is a psychoactive drug being developed by Merck and is currently in clinical trials. It is a so-called triple reuptake inhibitor (TRI), or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It is the (−)-enantiomer of DOV-216,303, and its (+)-enantiomer is DOV-21,947 (amitifadine).Instead of being developed for depression, DOV-102,677 is being developed for the treatment of alcoholism.IC50 values for the SERT, NET and DAT are 129 nM, 103 nM, and 133 nM.DOV-102,677 (20 mg/kg IP) increased extracellular levels of dopamine and serotonin in the prefrontal cortex to 320 and 280% above baseline 100 min after administration. Dopamine levels were stably increased for the duration (240 min) of the study, but serotonin levels declined to baseline by 200 min after administration. Norepinephrine levels increased linearly to a maximum of 348% at 240 min post-dosing.".
- Q5205903 iupacName "(5R)-5-(3,4-dichlorophenyl)bicyclo[3.1.0]hexane".
- Q5205903 pubchem "11637190".
- Q5205903 thumbnail DOV-102677.svg?width=300.
- Q5205903 wikiPageWikiLink Q14860818.
- Q5205903 wikiPageWikiLink Q14865372.
- Q5205903 wikiPageWikiLink Q14874257.
- Q5205903 wikiPageWikiLink Q15326.
- Q5205903 wikiPageWikiLink Q17166125.
- Q5205903 wikiPageWikiLink Q2198549.
- Q5205903 wikiPageWikiLink Q247489.
- Q5205903 wikiPageWikiLink Q2843568.
- Q5205903 wikiPageWikiLink Q286779.
- Q5205903 wikiPageWikiLink Q30612.
- Q5205903 wikiPageWikiLink Q3706669.
- Q5205903 wikiPageWikiLink Q4340209.
- Q5205903 wikiPageWikiLink Q5205904.
- Q5205903 wikiPageWikiLink Q52376.
- Q5205903 wikiPageWikiLink Q8732555.
- Q5205903 wikiPageWikiLink Q8919936.
- Q5205903 iupacName "-5".
- Q5205903 pubchem "11637190".
- Q5205903 type ChemicalSubstance.
- Q5205903 type Drug.
- Q5205903 type ChemicalObject.
- Q5205903 type Thing.
- Q5205903 type Q8386.
- Q5205903 comment "DOV-102,677 is a psychoactive drug being developed by Merck and is currently in clinical trials. It is a so-called triple reuptake inhibitor (TRI), or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).".
- Q5205903 label "DOV-102,677".
- Q5205903 depiction DOV-102677.svg.