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- Q5201170 subject Q6164904.
- Q5201170 subject Q7091706.
- Q5201170 subject Q7157144.
- Q5201170 subject Q8552399.
- Q5201170 subject Q8638071.
- Q5201170 subject Q8802898.
- Q5201170 abstract "The Cys-loop ligand-gated ion channel superfamily is composed of nicotinic acetylcholine, GABAA, GABAA-ρ, glycine and 5-HT3 receptors that are composed of five protein subunits that form a pentameric arrangement around a central pore. There are usually 2 alpha subunits and 3 other beta, gamma, or delta subunits (some consist of 5 alpha subunits). Cys-loop receptors possess a characteristic loop formed by a disulfide bond between two cysteine (Cys) residues 13 highly conserved amino acids apart near the N-terminal extracellular domain of the alpha subunit.All subunits consist of a conserved extracellular large N-terminal domain, three highly conserved transmembrane domains, a cytoplasmic loop of variable size and amino acid sequence, and a fourth transmembrane domain with a relatively short and variable extracellular C terminal. All alpha subunits have a characteristic cys-cys pair in the N-terminal extracellular domain, this is shown to be essential for agonist binding.The neurotransmitters bind at the interface between subunits in the extracellular domain.Each subunit contains 4-membrane-spanning alpha helices (M1, M2, M3, M4). The pore is formed primarily by M2 of the two alpha subunits.The M3-M4 linker is the intracellular domain that binds the cytoskeleton.".
- Q5201170 thumbnail NAchR-2BG9_default.png?width=300.
- Q5201170 wikiPageExternalLink cys-loop.htm.
- Q5201170 wikiPageExternalLink Acetylcholine_binding_protein.
- Q5201170 wikiPageWikiLink Q132560.
- Q5201170 wikiPageWikiLink Q162657.
- Q5201170 wikiPageWikiLink Q180623.
- Q5201170 wikiPageWikiLink Q186474.
- Q5201170 wikiPageWikiLink Q208467.
- Q5201170 wikiPageWikiLink Q3454515.
- Q5201170 wikiPageWikiLink Q412256.
- Q5201170 wikiPageWikiLink Q418536.
- Q5201170 wikiPageWikiLink Q4914012.
- Q5201170 wikiPageWikiLink Q5333998.
- Q5201170 wikiPageWikiLink Q60147.
- Q5201170 wikiPageWikiLink Q6164904.
- Q5201170 wikiPageWikiLink Q620730.
- Q5201170 wikiPageWikiLink Q62536.
- Q5201170 wikiPageWikiLink Q7030581.
- Q5201170 wikiPageWikiLink Q705605.
- Q5201170 wikiPageWikiLink Q7091706.
- Q5201170 wikiPageWikiLink Q7157144.
- Q5201170 wikiPageWikiLink Q798179.
- Q5201170 wikiPageWikiLink Q845326.
- Q5201170 wikiPageWikiLink Q8552399.
- Q5201170 wikiPageWikiLink Q8638071.
- Q5201170 wikiPageWikiLink Q8802898.
- Q5201170 wikiPageWikiLink Q899781.
- Q5201170 comment "The Cys-loop ligand-gated ion channel superfamily is composed of nicotinic acetylcholine, GABAA, GABAA-ρ, glycine and 5-HT3 receptors that are composed of five protein subunits that form a pentameric arrangement around a central pore. There are usually 2 alpha subunits and 3 other beta, gamma, or delta subunits (some consist of 5 alpha subunits).".
- Q5201170 label "Cys-loop receptors".
- Q5201170 depiction NAchR-2BG9_default.png.