Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q512313> ?p ?o }
- Q512313 subject Q16813146.
- Q512313 subject Q6500135.
- Q512313 subject Q6902168.
- Q512313 subject Q8863634.
- Q512313 abstract "Androgen insensitivity syndrome (AIS) is a condition that results in the partial or complete inability of cells to respond to androgens (androgenic hormones) whose purpose is to bind to androgen receptors to stimulate or control the development and maintenance of male physiological characteristics. This unresponsiveness of cells to the presence of androgenic hormones can either impair or prevent both the masculinization of male genitalia in a developing fetus and the development of male secondary sexual characteristics at puberty. The condition does not, however, significantly impair fetal development of female genitalia or pubertal development of female secondary sexual characteristics. As such, androgen insensitivity syndrome is of clinical significance only when it occurs in individuals with a Y-chromosome (or more specifically, an SRY gene), that is, persons that on a cellular level are genetically male.Clinical phenotypes in genetically male individuals with androgen insensitivity syndrome range from a normal external male body plus mild spermatogenic defect in post-pubertal stages, to a full female external body (although internal gonads are male testes instead of female ovaries) including post-pubertal external female characteristic development, despite the presence of a Y-chromosome. Both genetically male and genetically female individuals with AIS show reduced to no secondary terminal hair development.In genetic males with AIS, the condition is divided into three categories that are differentiated by the degree of genital masculinization: CAIS, or complete androgen insensitivity syndrome, is indicated when the external genitalia are that of a normal female; PAIS, or partial androgen insensitivity syndrome, is indicated when the external genitalia are partially, but not fully, masculinized; MAIS, or mild androgen insensitivity syndrome, is indicated when the external genitalia are that of a normal male.Androgen insensitivity syndrome is the largest single entity that leads to 46,XY undermasculinized genitalia in intersex persons. As with other intersex conditions, androgen insensitivity syndrome is independent of both sexual orientation and gender identity. The full spectrum of human sexual orientations has been reported among genetically female and genetically male AIS individuals alike, including: androphilia (i.e. sexual attraction to males) reported by most female-identified genetically-male female-bodied CAIS individuals; gynephilia (i.e. sexual attraction to females) reported even among some female-identified genetically-male female-bodied CAIS individuals in "lesbian" relationships; ambiphilia (bisexuality).Similarly, although AIS individuals may report any gender identity, a female gender identity is the gender identity of most, but not all, genetically-male female-bodied individuals with CAIS. Historically, however, the gender identity of CAIS individuals who identify as female has often been the cause of negative social bias and discrimination once their condition is made public. It is a matter of contention for some whether a CAIS individual with a female gender identity and external female body but genetic male sex should be regarded as "transgender". Some might regard such a person as "transgender" for identifying as female despite their genetic sex being male (even though they have an external female body), or they can be regarded as simply identifying as female in harmony to their external female body (despite their genetic male sex). Much social debate and litigation has resulted as a consequence of both arguments.Male gender identities among a minority of individuals with complete androgen insensitivity syndrome have also been reported. This has resulted in CAIS individuals who are genetically male with an external female body but a male gender identity (irrespective of sexual orientation). A male gender identity among this minority, however, does not eliminate social contentions among some as to whether these individuals are "transgender", as they might be regarded to be identifying as male despite their external female body (even though their genetic sex is male), or they can be regarded as simply identifying as male in harmony to their genetic male sex (despite their external female body). This contention can be seen even in modern medical literature, where in one case study the genetically male CAIS patient with male gender identity was said to "qualif[y] as female-to-male transsexual" after undergoing genital reconstruction surgery.".
- Q512313 icd10 "E34.5".
- Q512313 icd9 "259.5".
- Q512313 meshId "D013734".
- Q512313 omim "312300".
- Q512313 thumbnail Androgen_receptor_3-d_model.jpg?width=300.
- Q512313 wikiPageExternalLink Story?id=5465752&page=1.
- Q512313 wikiPageExternalLink www.aisdsd.org.
- Q512313 wikiPageExternalLink www.aissg.org.
- Q512313 wikiPageExternalLink www.aissga.org.au.
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