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- Q5013631 subject Q6543558.
- Q5013631 subject Q8617229.
- Q5013631 abstract "Template:ForCPEB, or cytoplasmic polyadenylation element binding protein, is a highly conserved RNA-binding protein that promotes the elongation of the polyadenine tail of messenger RNA. CPEB most commonly activates the target RNA for translation, but can also act as a repressor, dependent on its phosphorylation state. In animals, CPEB is expressed in several alternative splicing isoforms that are specific to particular tissues and functions, including the self-cleaving Mammalian CPEB3 ribozyme. CPEB was first identified in Xenopus oocytes and associated with meiosis; a role has also been identified in the spermatogenesis of Caenorhabditis elegans.CPEB is involved in closed-loop regulation of mRNAs that keeps them inactive. The closed-loop structure between the 3'UTR and 5'UTR inhibits translation. This has been observed in Xenopus laevis in which eIF4E bound to the 5' cap interacts with Maskin bound to CPEB on the 3' UTR creating translationally inactive transcripts. This translational inhibition is lifted once CPEB is phosphorylated, displacing the Maskin binding site, allowing for the polymerization of the PolyA tail, which can recruit the translational machinery by means of PABP. However, it is important to note that this mechanism has been under great scrutiny.".
- Q5013631 wikiPageWikiLink Q11053.
- Q5013631 wikiPageWikiLink Q1129238.
- Q5013631 wikiPageWikiLink Q1342298.
- Q5013631 wikiPageWikiLink Q1503548.
- Q5013631 wikiPageWikiLink Q15712714.
- Q5013631 wikiPageWikiLink Q162925.
- Q5013631 wikiPageWikiLink Q1698916.
- Q5013631 wikiPageWikiLink Q17916086.
- Q5013631 wikiPageWikiLink Q18030351.
- Q5013631 wikiPageWikiLink Q18032758.
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- Q5013631 wikiPageWikiLink Q312154.
- Q5013631 wikiPageWikiLink Q3246226.
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- Q5013631 wikiPageWikiLink Q36961.
- Q5013631 wikiPageWikiLink Q412148.
- Q5013631 wikiPageWikiLink Q43054.
- Q5013631 wikiPageWikiLink Q45422.
- Q5013631 wikiPageWikiLink Q47051.
- Q5013631 wikiPageWikiLink Q492.
- Q5013631 wikiPageWikiLink Q4995178.
- Q5013631 wikiPageWikiLink Q5201374.
- Q5013631 wikiPageWikiLink Q5408696.
- Q5013631 wikiPageWikiLink Q6543558.
- Q5013631 wikiPageWikiLink Q654718.
- Q5013631 wikiPageWikiLink Q6745754.
- Q5013631 wikiPageWikiLink Q8054.
- Q5013631 wikiPageWikiLink Q8617229.
- Q5013631 wikiPageWikiLink Q896177.
- Q5013631 wikiPageWikiLink Q91703.
- Q5013631 wikiPageWikiLink Q937624.
- Q5013631 comment "Template:ForCPEB, or cytoplasmic polyadenylation element binding protein, is a highly conserved RNA-binding protein that promotes the elongation of the polyadenine tail of messenger RNA. CPEB most commonly activates the target RNA for translation, but can also act as a repressor, dependent on its phosphorylation state.".
- Q5013631 label "CPEB".