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- Q5009957 subject Q7237908.
- Q5009957 abstract "CDKN2A, also known as cyclin-dependent kinase Inhibitor 2A, is a gene which in humans is located at chromosome 9, band 21.3. The gene codes for two proteins, including p16 (or p16INK4a) and p14arf. Both act as tumor suppressors by regulating the cell cycle. p16 inhibits cyclin dependent kinases 4 and 6 (CDK4 and CDK6) and thereby activates the retinoblastoma (Rb) family of proteins, which block traversal from G1 to S-phase. p14ARF (also known as p19ARF in the mouse) activates the p53 tumor suppressor. Somatic mutations of CDKN2A are common in the majority of human cancers, with estimates that CDKN2a is the second most commonly inactivated gene in cancer after p53. Germline mutations of CDKN2a are associated with familial melanoma, glioblastoma and pancreatic cancer.".
- Q5009957 entrezgene "1029".
- Q5009957 wikiPageWikiLink Q1216998.
- Q5009957 wikiPageWikiLink Q1269376.
- Q5009957 wikiPageWikiLink Q1455316.
- Q5009957 wikiPageWikiLink Q14818098.
- Q5009957 wikiPageWikiLink Q14907009.
- Q5009957 wikiPageWikiLink Q14911754.
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- Q5009957 wikiPageWikiLink Q180614.
- Q5009957 wikiPageWikiLink Q186889.
- Q5009957 wikiPageWikiLink Q188941.
- Q5009957 wikiPageWikiLink Q199602.
- Q5009957 wikiPageWikiLink Q201993.
- Q5009957 wikiPageWikiLink Q2070979.
- Q5009957 wikiPageWikiLink Q212961.
- Q5009957 wikiPageWikiLink Q22015156.
- Q5009957 wikiPageWikiLink Q2289513.
- Q5009957 wikiPageWikiLink Q282142.
- Q5009957 wikiPageWikiLink Q306383.
- Q5009957 wikiPageWikiLink Q40108.
- Q5009957 wikiPageWikiLink Q421136.
- Q5009957 wikiPageWikiLink Q422445.
- Q5009957 wikiPageWikiLink Q424396.
- Q5009957 wikiPageWikiLink Q653197.
- Q5009957 wikiPageWikiLink Q683498.
- Q5009957 wikiPageWikiLink Q7117832.
- Q5009957 wikiPageWikiLink Q7187.
- Q5009957 wikiPageWikiLink Q7237908.
- Q5009957 wikiPageWikiLink Q8054.
- Q5009957 wikiPageWikiLink Q840604.
- Q5009957 wikiPageWikiLink Q9690.
- Q5009957 type Biomolecule.
- Q5009957 type Protein.
- Q5009957 type Thing.
- Q5009957 type Q206229.
- Q5009957 type Q8054.
- Q5009957 comment "CDKN2A, also known as cyclin-dependent kinase Inhibitor 2A, is a gene which in humans is located at chromosome 9, band 21.3. The gene codes for two proteins, including p16 (or p16INK4a) and p14arf. Both act as tumor suppressors by regulating the cell cycle. p16 inhibits cyclin dependent kinases 4 and 6 (CDK4 and CDK6) and thereby activates the retinoblastoma (Rb) family of proteins, which block traversal from G1 to S-phase.".
- Q5009957 label "CDKN2A".