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- Q4993812 subject Q19363336.
- Q4993812 subject Q8593033.
- Q4993812 abstract "Halichondrin B is a large naturally occurring polyether macrolide originally isolated from the marine sponge Halichondria okadai by Hirata and Uemura in 1986. In the same report, these authors also reported the exquisite anticancer activity of halichondrin B against murine cancer cells both in culture and in in vivo studies. Halichondrin B was highly prioritized for development as a novel anticancer therapeutic by the United States National Cancer Institute and, in 1991, was the original test case for identification of mechanism of action (in this case, tubulin-targeted mitotic inhibitor) by NCI's then-brand-new "60-cell line screen" The complete chemical synthesis of halichondrin B was achieved by Yoshito Kishi and colleagues at Harvard University in 1992, an achievement that ultimately enabled the discovery and development of the structurally simplified and pharmaceutically optimized analog eribulin (E7389, ER-086526, NSC-707389). Eribulin was approved by the U.S. Food and Drug Administration on November 15, 2010, to treat patients with metastatic breast cancer who have received at least two prior chemotherapy regimens for late-stage disease, including both anthracycline- and taxane-based chemotherapies. Eribulin is marketed by Eisai Co. under the tradename Halaven.".
- Q4993812 iupacName "(1S,2S,2′S,3S,3aS,3a′S,5R,6S,7S,7′S,7aS,7a′S,9S,12S,14R,16R,18S,20S,22R,26R,28S,29S,30R,34R,37S,39R,40S,41R,43R,44S)-7,7′,14′′,29′′-tetramethyl-8′′,15′′-dimethylidene-2-(1,3,4-trihydroxybutyl)decahydro-3′H,32′′H-dispiro[furo[3,2-b]pyran-5,5′-furo[3,2-b]pyran-2′,24′′-[2,19,23,27,31,38,42,45,47,48,49]undecaoxaundecacyclo[32.9.2.1~3,40~.1~3,41~.1~6,9~.1~12,16]~.0~18,30~.0~20,28~.0~22,26~.0~37,44~.0~39,43~]nonatetracontan]-32′′-one".
- Q4993812 thumbnail Halichondrin_B.svg?width=300.
- Q4993812 wikiPageWikiLink Q103230.
- Q4993812 wikiPageWikiLink Q13371.
- Q4993812 wikiPageWikiLink Q19363336.
- Q4993812 wikiPageWikiLink Q3125963.
- Q4993812 wikiPageWikiLink Q408717.
- Q4993812 wikiPageWikiLink Q422492.
- Q4993812 wikiPageWikiLink Q422687.
- Q4993812 wikiPageWikiLink Q4774590.
- Q4993812 wikiPageWikiLink Q664846.
- Q4993812 wikiPageWikiLink Q6881918.
- Q4993812 wikiPageWikiLink Q8593033.
- Q4993812 wikiPageWikiLink Q903384.
- Q4993812 wikiPageWikiLink Q906949.
- Q4993812 iupacname "-77".
- Q4993812 type ChemicalCompound.
- Q4993812 type ChemicalSubstance.
- Q4993812 type ChemicalObject.
- Q4993812 type Thing.
- Q4993812 type Q11173.
- Q4993812 comment "Halichondrin B is a large naturally occurring polyether macrolide originally isolated from the marine sponge Halichondria okadai by Hirata and Uemura in 1986. In the same report, these authors also reported the exquisite anticancer activity of halichondrin B against murine cancer cells both in culture and in in vivo studies.".
- Q4993812 label "Halichondrin B".
- Q4993812 depiction Halichondrin_B.svg.
