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- Q488212 subject Q8934832.
- Q488212 subject Q9699097.
- Q488212 abstract "Microsatellite instability (MSI) is the condition of genetic hypermutability that results from impaired DNA mismatch repair (MMR). The presence of MSI represents phenotypic evidence that MMR is not functioning normally.MMR corrects errors that spontaneously occur during DNA replication, such as single base mismatches or short insertions and deletions. The proteins involved in MMR correct polymerase errors by forming a complex that binds to the mismatched section of DNA, excises the error, and inserts the correct sequence in its place. Cells with abnormally functioning MMR are unable to correct errors that occur during DNA replication and consequently accumulate errors. This causes the creation of novel microsatellite fragments. Polymerase chain reaction-based assays can reveal these novel microsatellites and provide evidence for the presence of MSI.Microsatellites are repeated sequences of DNA. These sequences can be made of repeating units of one to six base pairs in length. Although the length of these microsatellites is highly variable from person to person and contributes to the individual DNA "fingerprint", each individual has microsatellites of a set length. The most common microsatellite in humans is a dinucleotide repeat of the nucleotides C and A, which occurs tens of thousands of times across the genome. Microsatellites are also known as simple sequence repeats (SSRs).".
- Q488212 thumbnail Tumour-infiltrating_lymphocytes_-_2_--_extremely_high_mag.jpg?width=300.
- Q488212 wikiPageWikiLink Q145911.
- Q488212 wikiPageWikiLink Q14905392.
- Q488212 wikiPageWikiLink Q176996.
- Q488212 wikiPageWikiLink Q188941.
- Q488212 wikiPageWikiLink Q207551.
- Q488212 wikiPageWikiLink Q265193.
- Q488212 wikiPageWikiLink Q2984243.
- Q488212 wikiPageWikiLink Q418883.
- Q488212 wikiPageWikiLink Q425319.
- Q488212 wikiPageWikiLink Q612693.
- Q488212 wikiPageWikiLink Q7670163.
- Q488212 wikiPageWikiLink Q783644.
- Q488212 wikiPageWikiLink Q7908031.
- Q488212 wikiPageWikiLink Q827497.
- Q488212 wikiPageWikiLink Q8934832.
- Q488212 wikiPageWikiLink Q9699097.
- Q488212 comment "Microsatellite instability (MSI) is the condition of genetic hypermutability that results from impaired DNA mismatch repair (MMR). The presence of MSI represents phenotypic evidence that MMR is not functioning normally.MMR corrects errors that spontaneously occur during DNA replication, such as single base mismatches or short insertions and deletions.".
- Q488212 label "Microsatellite instability".
- Q488212 depiction Tumour-infiltrating_lymphocytes_-_2_--_extremely_high_mag.jpg.