Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q4880242> ?p ?o }
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- Q4880242 subject Q7145142.
- Q4880242 subject Q7310239.
- Q4880242 subject Q7334131.
- Q4880242 subject Q7335370.
- Q4880242 subject Q8878420.
- Q4880242 subject Q8919936.
- Q4880242 subject Q9052323.
- Q4880242 abstract "Befiradol (F-13,640; NLX-112) is a very potent and highly selective 5-HT1A receptor full agonist. It has powerful analgesic and antiallodynic effects comparable to those of high doses of opioid painkillers, but with fewer and less prominent side effects, as well as little or no development of tolerance with repeated use. A SAR study revealed that replacement of the dihalophenyl moiety by 3-benzothienyl increases maximal efficacy from 84% to 124% (Ki=2.7 nM).Befiradol was discovered and developed by Pierre Fabre Médicament, a French pharmaceuticals company. In September 2013, befiradol was out-licensed to Neurolixis, a California-based biotechnology company. Neurolixis announced that it intends to re-purpose befiradol for the treatment of Levodopa-induced dyskinesia in Parkinson's disease. In 2015, preclinical data was published describing the activity of befiradol in animal models of Parkinson's disease.".
- Q4880242 atcPrefix "none".
- Q4880242 casNumber "208110-64-9".
- Q4880242 fdaUniiCode "RAT9OHA1YH".
- Q4880242 iupacName "3-chloro-4-fluorophenyl-[4-fluoro-4-([(5-methylpyridin-2-yl)methylamino]methyl)piperidin-1-yl]methanone".
- Q4880242 pubchem "9865384".
- Q4880242 thumbnail F-13640_structure.png?width=300.
- Q4880242 wikiPageWikiLink Q11085.
- Q4880242 wikiPageWikiLink Q1425425.
- Q4880242 wikiPageWikiLink Q17091480.
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- Q4880242 wikiPageWikiLink Q389934.
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- Q4880242 wikiPageWikiLink Q427523.
- Q4880242 wikiPageWikiLink Q4914025.
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- Q4880242 wikiPageWikiLink Q5458730.
- Q4880242 wikiPageWikiLink Q626597.
- Q4880242 wikiPageWikiLink Q6535765.
- Q4880242 wikiPageWikiLink Q7145142.
- Q4880242 wikiPageWikiLink Q7310239.
- Q4880242 wikiPageWikiLink Q7334131.
- Q4880242 wikiPageWikiLink Q7335370.
- Q4880242 wikiPageWikiLink Q8878420.
- Q4880242 wikiPageWikiLink Q8919936.
- Q4880242 wikiPageWikiLink Q9052323.
- Q4880242 atcPrefix "none".
- Q4880242 casNumber "208110".
- Q4880242 iupacName "3".
- Q4880242 pubchem "9865384".
- Q4880242 unii "RAT9OHA1YH".
- Q4880242 type ChemicalSubstance.
- Q4880242 type Drug.
- Q4880242 type ChemicalObject.
- Q4880242 type Thing.
- Q4880242 type Q8386.
- Q4880242 comment "Befiradol (F-13,640; NLX-112) is a very potent and highly selective 5-HT1A receptor full agonist. It has powerful analgesic and antiallodynic effects comparable to those of high doses of opioid painkillers, but with fewer and less prominent side effects, as well as little or no development of tolerance with repeated use.".
- Q4880242 label "Befiradol".
- Q4880242 depiction F-13640_structure.png.