Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q4775330> ?p ?o }
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- Q4775330 subject Q6306357.
- Q4775330 subject Q7056690.
- Q4775330 subject Q7300121.
- Q4775330 abstract "In pharmacology, an antitarget is a receptor, enzyme, or other biological target that, when affected by a drug, causes undesirable side-effects. During drug design and development, it is important for pharmaceutical companies to ensure that new drugs do not show significant activity at any of a range of antitargets, most of which are discovered largely by chance.Among the best-known and most significant antitargets are the hERG channel and the 5-HT2B receptor, both of which causing long-term problems with heart function that can prove fatal (long QT syndrome and cardiac fibrosis, respectively), in a small but unpredictable proportion of users. Both of these targets were discovered as a result of high levels of distinctive side-effects during the marketing of certain medicines, and, while some older drugs with significant hERG activity are still used with caution, most drugs that have been found to be strong 5-HT2B agonists were withdrawn from the market, and any new compound will almost always be discontinued from further development if initial screening shows high affinity for these targets.".
- Q4775330 wikiPageWikiLink Q128406.
- Q4775330 wikiPageWikiLink Q14865830.
- Q4775330 wikiPageWikiLink Q18027434.
- Q4775330 wikiPageWikiLink Q2047938.
- Q4775330 wikiPageWikiLink Q208467.
- Q4775330 wikiPageWikiLink Q2198549.
- Q4775330 wikiPageWikiLink Q2991682.
- Q4775330 wikiPageWikiLink Q5038318.
- Q4775330 wikiPageWikiLink Q6306357.
- Q4775330 wikiPageWikiLink Q653924.
- Q4775330 wikiPageWikiLink Q7056690.
- Q4775330 wikiPageWikiLink Q7300121.
- Q4775330 wikiPageWikiLink Q8047.
- Q4775330 wikiPageWikiLink Q904407.
- Q4775330 comment "In pharmacology, an antitarget is a receptor, enzyme, or other biological target that, when affected by a drug, causes undesirable side-effects.".
- Q4775330 label "Antitarget".