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- Q4774725 subject Q8256069.
- Q4774725 abstract "Antifolates are drugs that antagonise (that is, block) the actions of folic acid (vitamin B9). Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis. Some such as proguanil, pyrimethamine and trimethoprim selectively inhibit folate's actions in microbial organisms such as bacteria, protozoa and fungi. The majority of antifolates work by inhibiting dihydrofolate reductase (DHFR).".
- Q4774725 thumbnail Dihydrofolate_reductase_1DRF.png?width=300.
- Q4774725 wikiPageWikiLink Q1053948.
- Q4774725 wikiPageWikiLink Q1074.
- Q4774725 wikiPageWikiLink Q1077603.
- Q4774725 wikiPageWikiLink Q1151482.
- Q4774725 wikiPageWikiLink Q1161568.
- Q4774725 wikiPageWikiLink Q12156.
- Q4774725 wikiPageWikiLink Q127060.
- Q4774725 wikiPageWikiLink Q1345792.
- Q4774725 wikiPageWikiLink Q14819367.
- Q4774725 wikiPageWikiLink Q15304877.
- Q4774725 wikiPageWikiLink Q15401586.
- Q4774725 wikiPageWikiLink Q154878.
- Q4774725 wikiPageWikiLink Q179945.
- Q4774725 wikiPageWikiLink Q187255.
- Q4774725 wikiPageWikiLink Q1878682.
- Q4774725 wikiPageWikiLink Q199804.
- Q4774725 wikiPageWikiLink Q221668.
- Q4774725 wikiPageWikiLink Q28472.
- Q4774725 wikiPageWikiLink Q2915477.
- Q4774725 wikiPageWikiLink Q3208529.
- Q4774725 wikiPageWikiLink Q327298.
- Q4774725 wikiPageWikiLink Q3658562.
- Q4774725 wikiPageWikiLink Q415220.
- Q4774725 wikiPageWikiLink Q420607.
- Q4774725 wikiPageWikiLink Q421072.
- Q4774725 wikiPageWikiLink Q422232.
- Q4774725 wikiPageWikiLink Q422665.
- Q4774725 wikiPageWikiLink Q546523.
- Q4774725 wikiPageWikiLink Q549534.
- Q4774725 wikiPageWikiLink Q631521.
- Q4774725 wikiPageWikiLink Q637059.
- Q4774725 wikiPageWikiLink Q746209.
- Q4774725 wikiPageWikiLink Q8256069.
- Q4774725 wikiPageWikiLink Q8386.
- Q4774725 wikiPageWikiLink Q911386.
- Q4774725 wikiPageWikiLink Q912894.
- Q4774725 wikiPageWikiLink Q963944.
- Q4774725 comment "Antifolates are drugs that antagonise (that is, block) the actions of folic acid (vitamin B9). Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis.".
- Q4774725 label "Antifolate".
- Q4774725 depiction Dihydrofolate_reductase_1DRF.png.