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- Q4734908 subject Q7403984.
- Q4734908 subject Q8527140.
- Q4734908 subject Q8617855.
- Q4734908 abstract "Alpha-Melanocyte-stimulating hormone α-Melanocyte-stimulating hormone (α-MSH) is an endogenous peptide hormone and neuropeptide of the melanocortin family, with a tridecapeptide structure and the amino acid sequence Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2. It is the most important of the melanocyte-stimulating hormones (MSHs) (also known as melanotropins) in stimulating melanogenesis, a process that in mammals (including humans) is responsible for pigmentation primarily of the hair and skin. It also plays a role in feeding behavior, energy homeostasis, sexual activity, and protection against ischemia and reperfusion injury.α-MSH is a non-selective full agonist of the melanocortin receptors MC1 (Ki = 0.230 nM), MC3 (Ki = 31.5 nM), MC4 (Ki = 900 nM), and MC5 (Ki = 7160 nM), but not MC2 (which is exclusive for adrenocorticotropic hormone (ACTH)). Activation of the MC1 receptor is responsible for its effect on pigmentation, whereas its regulation of appetite, metabolism, and sexual behavior is mediated through both the MC3 and MC4 receptors.It is generated as a proteolyic cleavage product from ACTH (1-13), which is in turn a cleavage product of proopiomelanocortin (POMC).A few synthetic analogues of α-MSH have been investigated as medicinal drugs due to their photoprotective effects against ultraviolet (UV) radiation from the sun. They include afamelanotide (melanotan) and melanotan II, the former of which being in phase-III clinical trials in the United States. Bremelanotide, another analogue of α-MSH, is currently under development not as a photoprotective agent, but instead for the treatment of sexual dysfunction. All of these drugs have significantly greater potencies than α-MSH, along with improved pharmacokinetics and distinctive selectivity profiles.".
- Q4734908 iupacName "N-acetyl-(L)-seryl-(L)-tyrosyl-(L)-seryl-(L)-methionyl-(L)-α-glutamyl-(L)-histidyl-(L)-phenylalanyl-(L)-arginyl-(L)-tryptophylglycyl-(L)-lysyl-(L)-prolyl-(L)-valinamide".
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- Q4734908 wikiPageWikiLink Q7403984.
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- Q4734908 wikiPageWikiLink Q8527140.
- Q4734908 wikiPageWikiLink Q8617855.
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- Q4734908 wikiPageWikiLink Q910979.
- Q4734908 iupacname "N-acetyl-(L)-seryl-(L)-tyrosyl-(L)-seryl-(L)-methionyl-(L)-α-glutamyl-(L)-histidyl-(L)-phenylalanyl-(L)-arginyl-(L)-tryptophylglycyl-(L)-lysyl-(L)-prolyl-(L)-valinamide".
- Q4734908 name "α-Melanocyte-stimulating hormone".
- Q4734908 type ChemicalCompound.
- Q4734908 type ChemicalSubstance.
- Q4734908 type ChemicalObject.
- Q4734908 type Thing.
- Q4734908 type Q11173.
- Q4734908 comment "Alpha-Melanocyte-stimulating hormone α-Melanocyte-stimulating hormone (α-MSH) is an endogenous peptide hormone and neuropeptide of the melanocortin family, with a tridecapeptide structure and the amino acid sequence Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2.".
- Q4734908 label "Alpha-Melanocyte-stimulating hormone".
- Q4734908 name "α-Melanocyte-stimulating hormone".