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- Q4677991 subject Q9089708.
- Q4677991 abstract "In molecular biology, the Acyl-CoA-binding protein (ACBP) is a small (10 Kd) protein that binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. ACBP is also known as diazepam binding inhibitor (DBI) or endozepine (EP) because of its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.ACBP is a highly conserved protein of about 90 amino acids that is found in all four eukaryotic kingdoms, Animalia, Plantae, Fungi and Protista, and in some eubacterial species.Although ACBP occurs as a completely independent protein, intact ACB domains have been identified in a number of large, multifunctional proteins in a variety of eukaryotic species. These include large membrane-associated proteins with N-terminal ACB domains, multifunctional enzymes with both ACB and peroxisomal enoyl-CoA Delta(3), Delta(2)-enoyl-CoA isomerase domains, and proteins with both an ACB domain and ankyrin repeats.The ACB domain consists of four alpha-helices arranged in a bowl shape with a highly exposed acyl-CoA-binding site. The ligand is bound through specific interactions with residues on the protein, most notably several conserved positive charges that interact with the phosphate group on the adenosine-3'phosphate moiety, and the acyl chain is sandwiched between the hydrophobic surfaces of CoA and the protein.Other proteins containing an ACB domain include: Endozepine-like peptide (ELP) (gene DBIL5) from mouse. ELP is a testis-specific ACBP homologue that may be involved in the energy metabolism of the mature sperm.MA-DBI, a transmembrane protein of unknown function which has been found in mammals. MA-DBI contains a N-terminal ACB domain.DRS-1, a human protein of unknown function that contains a N-terminal ACB domain and a C-terminal enoyl-CoA isomerase/hydratase domain.↑ ↑ ↑ 3.0 3.1 ↑ ↑ ↑".
- Q4677991 symbol "ACBP".
- Q4677991 thumbnail PDB_1hb8_EBI.jpg?width=300.
- Q4677991 wikiPageWikiLink Q101487.
- Q4677991 wikiPageWikiLink Q1057.
- Q4677991 wikiPageWikiLink Q11379.
- Q4677991 wikiPageWikiLink Q118026.
- Q4677991 wikiPageWikiLink Q15978631.
- Q4677991 wikiPageWikiLink Q172847.
- Q4677991 wikiPageWikiLink Q177811.
- Q4677991 wikiPageWikiLink Q17913005.
- Q4677991 wikiPageWikiLink Q19088.
- Q4677991 wikiPageWikiLink Q208467.
- Q4677991 wikiPageWikiLink Q210021.
- Q4677991 wikiPageWikiLink Q224180.
- Q4677991 wikiPageWikiLink Q2699537.
- Q4677991 wikiPageWikiLink Q283399.
- Q4677991 wikiPageWikiLink Q3824358.
- Q4677991 wikiPageWikiLink Q419968.
- Q4677991 wikiPageWikiLink Q424204.
- Q4677991 wikiPageWikiLink Q4766126.
- Q4677991 wikiPageWikiLink Q4995178.
- Q4677991 wikiPageWikiLink Q5376579.
- Q4677991 wikiPageWikiLink Q6507061.
- Q4677991 wikiPageWikiLink Q7377.
- Q4677991 wikiPageWikiLink Q7432.
- Q4677991 wikiPageWikiLink Q764.
- Q4677991 wikiPageWikiLink Q8047.
- Q4677991 wikiPageWikiLink Q8054.
- Q4677991 wikiPageWikiLink Q8066.
- Q4677991 wikiPageWikiLink Q83310.
- Q4677991 wikiPageWikiLink Q83871.
- Q4677991 wikiPageWikiLink Q896177.
- Q4677991 wikiPageWikiLink Q898273.
- Q4677991 wikiPageWikiLink Q899107.
- Q4677991 wikiPageWikiLink Q9089708.
- Q4677991 symbol "ACBP".
- Q4677991 type Biomolecule.
- Q4677991 type Protein.
- Q4677991 type Thing.
- Q4677991 type Q206229.
- Q4677991 type Q8054.
- Q4677991 comment "In molecular biology, the Acyl-CoA-binding protein (ACBP) is a small (10 Kd) protein that binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. ACBP is also known as diazepam binding inhibitor (DBI) or endozepine (EP) because of its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor.".
- Q4677991 label "Acyl-CoA-binding protein".
- Q4677991 depiction PDB_1hb8_EBI.jpg.