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- Q4634148 subject Q7139608.
- Q4634148 subject Q7145142.
- Q4634148 subject Q8887197.
- Q4634148 subject Q9056368.
- Q4634148 abstract "3-Hydroxymorphinan (3-HM), or morphinan-3-ol, is a psychoactive drug of the morphinan family. It is the racemic version of norlevorphanol.The dextrorotatory stereoisomer of the compound is an active metabolite of dextromethorphan, dextrorphan, and 3-methoxymorphinan, and similarly to them has potent neuroprotective and neurotrophic effects on LTS- and MPTP-treated dopaminergic neurons of the nigrostriatal pathway, but notably without producing any neuropsychotoxic side effects (e.g., dissociation or hallucinations) or having any anticonvulsant actions. It does not seem to bind to the NMDA receptor, and instead, its neuroprotective properties appear result from inhibition of glutamate release via the suppression of presynaptic voltage-dependent Ca2+ entry and protein kinase C activity. In any case, as such, the compound has been investigated as a potential antiparkinsonian agent. A prodrug, GCC1290K, has been developed on account of 3-HM's poor bioavailability (18%), and a New Drug Application has been approved for it by the United States Food and Drug Administration. It is currently undergoing clinical trials for the treatment of Parkinson's disease. It does not have a Controlled Substances Act 1970 schedule, ACSCN, or annual aggregate manufacturing quota and may not necessarily be controlled, whilst norlevorphanol is; none of the dextrorotary derivatives of the dromoran and norlevorphanol sub-families of morphinan derivatives are controlled as they do not have opioid activity but the other racemic compounds are.3-HM's levorotatory stereoisomer, norlevorphanol, in contrast to (+)-3-HM, is an opioid analgesic. It was never marketed as such however, probably due to a combination of the facts that norlevorphanol has low bioavailability and that its potency is diminished compared to its N-methylated analogue levorphanol.".
- Q4634148 atcPrefix "None".
- Q4634148 bioavailability "18.0".
- Q4634148 casNumber "39131-41-4".
- Q4634148 iupacName "(±)-morphinan-3-ol".
- Q4634148 thumbnail 3-Hydroxymorphinan.svg?width=300.
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- Q4634148 wikiPageWikiLink Q7139608.
- Q4634148 wikiPageWikiLink Q7145142.
- Q4634148 wikiPageWikiLink Q8887197.
- Q4634148 wikiPageWikiLink Q9056368.
- Q4634148 atcPrefix "None".
- Q4634148 bioavailability "18.0".
- Q4634148 casNumber "39131".
- Q4634148 iupacName "-morphinan-3-ol".
- Q4634148 type ChemicalSubstance.
- Q4634148 type Drug.
- Q4634148 type ChemicalObject.
- Q4634148 type Thing.
- Q4634148 type Q8386.
- Q4634148 comment "3-Hydroxymorphinan (3-HM), or morphinan-3-ol, is a psychoactive drug of the morphinan family.".
- Q4634148 label "3-Hydroxymorphinan".
- Q4634148 depiction 3-Hydroxymorphinan.svg.