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- Q46292 subject Q7424714.
- Q46292 subject Q8351235.
- Q46292 subject Q8802898.
- Q46292 abstract "Cyclin-dependent kinases (CDKs) are a family of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved. In fact, yeast cells can proliferate normally when their CDK gene has been replaced with the homologous human gene. CDKs are relatively small proteins, with molecular weights ranging from 34 to 40 kDa, and contain little more than the kinase domain.By definition, a CDK binds a regulatory protein called a cyclin. Without cyclin, CDK has little kinase activity; only the cyclin-CDK complex is an active kinase. CDKs phosphorylate their substrates on serines and threonines, so they are serine-threonine kinases. The consensus sequence for the phosphorylation site in the amino acid sequence of a CDK substrate is [S/T*]PX[K/R], where S/T* is the phosphorylated serine or threonine, P is proline, X is any amino acid, K is lysine, and R is arginine.".
- Q46292 ecNumber "2.7.11.22".
- Q46292 thumbnail Cell_Cycle_2.png?width=300.
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- Q46292 ecNumber "2.7".
- Q46292 name "Cyclin-dependent kinase".
- Q46292 type Biomolecule.
- Q46292 type Enzyme.
- Q46292 type Thing.
- Q46292 type Q206229.
- Q46292 type Q8047.
- Q46292 comment "Cyclin-dependent kinases (CDKs) are a family of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved. In fact, yeast cells can proliferate normally when their CDK gene has been replaced with the homologous human gene.".
- Q46292 label "Cyclin-dependent kinase".
- Q46292 depiction Cell_Cycle_2.png.
- Q46292 name "Cyclin-dependent kinase".