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- Q4596897 subject Q7162167.
- Q4596897 abstract "2-Methoxyestradiol (2ME2) is a natural metabolite of estradiol. As an experimental drug candidate, it is being developed under the tradename of Panzem. It prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis), hence it is an angiogenesis inhibitor.It also acts as a vasodilator.2ME2 is derived from estrogen, although it binds poorly to known estrogen receptors.It induces apoptosis in some cancer cell lines.It has undergone Phase 1 clinical trials against breast cancer.A phase II trial of 18 advanced ovarian cancer patients reported encouraging results in Oct 2007.Preclinical models also suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis. Several studies have been conducted showing 2ME2 is a microtubule-inhibitor and effective against prostate cancer in rodents.The CAS name for 2ME2 is (17 beta)-2-methoxyestra-1,3,5(10)-triene-3,17-diol.".
- Q4596897 casNumber "362-07-2".
- Q4596897 chEBI "28955".
- Q4596897 fdaUniiCode "6I2QW73SR5".
- Q4596897 iupacName "(8R,9S,13S,14S,17S)-2-Methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol".
- Q4596897 pubchem "66414".
- Q4596897 thumbnail 2-Methoxyestradiol.svg?width=300.
- Q4596897 wikiPageExternalLink detail.go?type=chem&acc=C022830.
- Q4596897 wikiPageExternalLink dispprod.php?ItemId=78389.
- Q4596897 wikiPageWikiLink Q101991.
- Q4596897 wikiPageWikiLink Q1216998.
- Q4596897 wikiPageWikiLink Q128581.
- Q4596897 wikiPageWikiLink Q14599311.
- Q4596897 wikiPageWikiLink Q14859627.
- Q4596897 wikiPageWikiLink Q172341.
- Q4596897 wikiPageWikiLink Q187255.
- Q4596897 wikiPageWikiLink Q208467.
- Q4596897 wikiPageWikiLink Q2198549.
- Q4596897 wikiPageWikiLink Q277954.
- Q4596897 wikiPageWikiLink Q30612.
- Q4596897 wikiPageWikiLink Q422416.
- Q4596897 wikiPageWikiLink Q5155628.
- Q4596897 wikiPageWikiLink Q539568.
- Q4596897 wikiPageWikiLink Q574834.
- Q4596897 wikiPageWikiLink Q7162167.
- Q4596897 wikiPageWikiLink Q911173.
- Q4596897 wikiPageWikiLink Q988343.
- Q4596897 casNumber "0362-07-02".
- Q4596897 chebi "28955".
- Q4596897 iupacName "-2".
- Q4596897 pubchem "66414".
- Q4596897 unii "6".
- Q4596897 type ChemicalSubstance.
- Q4596897 type Drug.
- Q4596897 type ChemicalObject.
- Q4596897 type Thing.
- Q4596897 type Q8386.
- Q4596897 comment "2-Methoxyestradiol (2ME2) is a natural metabolite of estradiol. As an experimental drug candidate, it is being developed under the tradename of Panzem.".
- Q4596897 label "2-Methoxyestradiol".
- Q4596897 depiction 2-Methoxyestradiol.svg.