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- Q4355943 subject Q7424714.
- Q4355943 subject Q8802909.
- Q4355943 abstract "G protein-coupled receptor kinases (GRKs, GPCRKs) are a family of protein kinases that regulate the activity of G protein-coupled receptors (GPCRs) by phosphorylating their intracellular domains after their associated G proteins have been released and activated. The phosphorylated serine and threonine residues act as binding sites for arrestin proteins that prevent the reassociation of the G proteins with their receptors, thereby preventing reactivation of the signaling pathway.GRKs regulate also cellular responses independent of their kinase activity. In particular, G protein-coupled receptor kinase 2 interacts with a diverse repertoire of non-GPCR substrates.GRK1 is involved with Rhodopsin phosphorlylation and deactivation. Defects in GRK1 result in Oguchi disease 2.".
- Q4355943 ecNumber "2.7.11.16".
- Q4355943 thumbnail Gprotein-coupled_receptor_kinase.png?width=300.
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- Q4355943 wikiPageWikiLink Q7424714.
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- Q4355943 wikiPageWikiLink Q8802909.
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- Q4355943 wikiPageWikiLink Q9377.
- Q4355943 ecNumber "2.7".
- Q4355943 name "G protein-coupled receptor kinase".
- Q4355943 type Biomolecule.
- Q4355943 type Enzyme.
- Q4355943 type Thing.
- Q4355943 type Q206229.
- Q4355943 type Q8047.
- Q4355943 comment "G protein-coupled receptor kinases (GRKs, GPCRKs) are a family of protein kinases that regulate the activity of G protein-coupled receptors (GPCRs) by phosphorylating their intracellular domains after their associated G proteins have been released and activated.".
- Q4355943 label "G protein-coupled receptor kinase".
- Q4355943 depiction Gprotein-coupled_receptor_kinase.png.
- Q4355943 name "G protein-coupled receptor kinase".